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Titolo:
Arrhythmogenic ionic remodeling - Adaptive responses with maladaptive consequences
Autore:
Nattel, S; Khairy, P; Schram, G;
Indirizzi:
Univ Montreal, Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada Univ Montreal Montreal PQ Canada H1T 1C8 tr, Montreal, PQ H1T 1C8, Canada Univ Montreal, Montreal Heart Inst, Dept Med, Montreal, PQ H1T 1C8, CanadaUniv Montreal Montreal PQ Canada H1T 1C8 ed, Montreal, PQ H1T 1C8, Canada McGill Univ, Dept Pharmacol & Toxicol, Montreal, PQ H3A 2T5, Canada McGillUniv Montreal PQ Canada H3A 2T5 icol, Montreal, PQ H3A 2T5, Canada
Titolo Testata:
TRENDS IN CARDIOVASCULAR MEDICINE
fascicolo: 7, volume: 11, anno: 2001,
pagine: 295 - 301
SICI:
1050-1738(200110)11:7<295:AIR-AR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ATRIAL-FIBRILLATION; INDUCED HEART-FAILURE; RAT VENTRICULAR MYOCYTES; FAILING HUMAN MYOCARDIUM; ADENOVIRAL GENE-TRANSFER; CHRONIC DOG-MODEL; REPOLARIZATION ABNORMALITIES; CONTRACTILE DYSFUNCTION; NA+-CA2+ EXCHANGER; ACTION-POTENTIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Nattel, S Univ Montreal, Montreal Heart Inst, Res Ctr, 5000 Belanger St E,Montreal,PQ H1T 1C8, Canada Univ Montreal 5000 Belanger St E Montreal PQ Canada H1T 1C8 nada
Citazione:
S. Nattel et al., "Arrhythmogenic ionic remodeling - Adaptive responses with maladaptive consequences", TREND CARD, 11(7), 2001, pp. 295-301

Abstract

Compensatory changes in ion transport mechanisms occur in response to a variety of cardiac disease processes. Recent work has demonstrated that theseadaptive responses can produce the arrhythmogenic substrate for a variety of important cardiac rhythm disorders. Two important paradigms are atrial tachycardia-induced remodeling and ionic remodeling caused by congestive heart failure. Atrial tachycardia promotes cellular Ca2+ loading and downregulates a variety of ion channels, particularly L-type Ca2+ channels, thereby promoting the occurrence and maintenance of atrial fibrillation. Congestiveheart failure alters the expression and function of a variety of membrane transport processes, including several K+-channels and key Ca2+-transport systems, favoring the occurrence of arrhythmogenic afterdepolarizations. An improved understanding of the mechanisms and consequences of arrhythmogenicionic remodeling promises to lead to novel and improved therapeutic approaches. (Trends Cardiovasc Med 2001; 11:295-301). (C) 2001, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:17:25