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Titolo:
Comparison of oral and intraperitoneal toxicity of yessotoxin towards mice
Autore:
Aune, T; Sorby, R; Yasumoto, T; Ramstad, H; Landsverk, T;
Indirizzi:
Norwegian Sch Vet Sci, Dept Pharmacol Microbiol & Food Hyg, N-0033 Oslo, Norway Norwegian Sch Vet Sci Oslo Norway N-0033 & Food Hyg, N-0033 Oslo, Norway Norwegian Sch Vet Sci, Dept Morphol Genet & Aquat Biol, N-0033 Oslo, Norway Norwegian Sch Vet Sci Oslo Norway N-0033 Aquat Biol, N-0033 Oslo, Norway Japan Food Res Labs, Tama Lab, Tokyo, Japan Japan Food Res Labs Tokyo Japan n Food Res Labs, Tama Lab, Tokyo, Japan
Titolo Testata:
TOXICON
fascicolo: 1, volume: 40, anno: 2002,
pagine: 77 - 82
SICI:
0041-0101(200201)40:1<77:COOAIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN PHOSPHATASES; CONFIGURATION; ACID;
Keywords:
yessotoxin; YTX; oral toxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Aune, T Norwegian Sch Vet Sci, Dept Pharmacol Microbiol & Food Hyg, POB 8146, N-0033 Oslo, Norway Norwegian Sch Vet Sci POB 8146 Oslo Norway N-0033 33 Oslo, Norway
Citazione:
T. Aune et al., "Comparison of oral and intraperitoneal toxicity of yessotoxin towards mice", TOXICON, 40(1), 2002, pp. 77-82

Abstract

Currently, yessotoxin is regulated among the toxins in the diarrhetic shellfish poisoning (DSP) complex. Yessotoxin is equally acutely toxic towards mice upon intraperitoneal injections as those algal toxins giving diarrhea,but is not diarrheagenic. Its presence in mussels may therefore lead to overestimation of risk of DSP in consumers when the standard mouse bioassay is used. Arguments are presented for the use of analytical methods instead of the mouse bioassay for the diarrheagenic DSP toxins, and yessotoxin. Yessotoxin was found to be more than ten times less toxic to mice via the oral route, compared with intraperitoneal injections. Even at 10 mg/kg bodyweight, the highest dose ever tested orally, yessotoxin did not kill the mice. By means of light microscopy of several organs, moderate changes were only observed in the heart. Ultrastructural studies revealed swelling of heart muscle cells leading to separation of the organelles. Effects were mostpronounced close to the capillaries. The pathological changes were clearlydose dependent, and the lowest oral dose where any effects were seen was 2.5 mg yessotoxin per kg. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:06:50