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Titolo:
Biochemical characterization of fibrinogenolytic serine proteinases from Vipera lebetina snake venom
Autore:
Samel, M; Subbi, J; Siigur, J; Siigur, E;
Indirizzi:
Natl Inst Chem Phys & Biophys, EE-12618 Tallinn, Estonia Natl Inst Chem Phys & Biophys Tallinn Estonia EE-12618 Tallinn, Estonia
Titolo Testata:
TOXICON
fascicolo: 1, volume: 40, anno: 2002,
pagine: 51 - 54
SICI:
0041-0101(200201)40:1<51:BCOFSP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-SEQUENCE; V ACTIVATING ENZYME; BETA-FIBRINOGENASE; BOTHROPS-JARARACA; PURIFICATION; CDNA; PROTEASE; BJ;
Keywords:
snake venom; vipera lebetina; alpha-fibrinogenase; beta-fibrinogenase; glycoprotein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Siigur, E Natl Inst Chem Phys & Biophys, Akad tee 3, EE-12618 Tallinn, Estonia Natl Inst Chem Phys & Biophys Akad tee 3 Tallinn Estonia EE-12618
Citazione:
M. Samel et al., "Biochemical characterization of fibrinogenolytic serine proteinases from Vipera lebetina snake venom", TOXICON, 40(1), 2002, pp. 51-54

Abstract

Two glycosylated serine fibrinogenases isolated from Vipera lebetina venomhave homologous N-terminal sequences and antigenic determinants but can beclearly differentiated according to substrate specificity, glycosylation levels, molecular mass and fibrinogen degradation. alpha -Fibrinogenase has no homolog among known serine proteinases. It has N-terminal similarity with snake venom arginine esterases but does not hydrolyze the esters of arginine, lysine and tyrosine. The enzyme has strong proteolytic activity and degrades alpha -chain of fibrinogen altering its clottability by thrombin. beta -Fibrinogenase is a typical arginine esterase which hydrolyzes esters and amides of arginine and attacks the beta -chain of fibrinogen. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:43:58