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Titolo:
Mitochondrial oxidative damage and myocardial fibrosis in rats chronicallyintoxicated with moderate doses of ethanol
Autore:
Vendemiale, G; Grattagliano, I; Altomare, E; Serviddio, G; Portincasa, P; Prigigallo, F; Palasciano, G;
Indirizzi:
Univ Bari, Dipartimento Med Interna & Pubbl, Gianluigi Vendemiale, I-70124Bari, Italy Univ Bari Bari Italy I-70124 l, Gianluigi Vendemiale, I-70124Bari, Italy
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 2-3, volume: 123, anno: 2001,
pagine: 209 - 216
SICI:
0378-4274(20010915)123:2-3<209:MODAMF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOLIC LIVER-DISEASE; CORONARY HEART-DISEASE; LIPID-PEROXIDATION; IN-VITRO; GLUTATHIONE; CONSUMPTION; PROTEINS; SYSTEMS; ACETALDEHYDE; FIBROGENESIS;
Keywords:
alcohol; glutathione; malondialdehyde; mitochondria; myocardial fibrosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Vendemiale, G Univ Bari, Dipartimento Med Interna & Pubbl, Gianluigi Vendemiale, Piazza G Cesare 11, I-70124 Bari, Italy Univ Bari Piazza G Cesare 11Bari Italy I-70124 Bari, Italy
Citazione:
G. Vendemiale et al., "Mitochondrial oxidative damage and myocardial fibrosis in rats chronicallyintoxicated with moderate doses of ethanol", TOX LETT, 123(2-3), 2001, pp. 209-216

Abstract

Mitochondrial oxidative balance and myocardial fibrosis were investigated in pair-fed rats received ethanol (3%) or saccharose in drinking water for 8 weeks. The concentrations of glutathione, malondialdehyde, protein carbonyls and sulfhydrils were determined. The presence and distribution of fibronectin were detected by immunchistochemistry. The myocardial concentrationsof reduced glutathione and protein sulfhydrils were lower in ethanol treated rats. The oxidised/reduced glutathione ratio, the levels of malondialdehyde and protein carbonyls were higher in ethanol-treated rats. The mitochondrial amount of proteins, glutathione and protein sulfhydrils were lower inethanol treated rats, whereas the content or protein carbonyls and malondialdehyde were higher. Accumulation of fibronectin was detected at subepicardial and subendocardial districts in ethanol-treated rats, with moderate degree of fibrosis in 20% of the cases. In conclusion, moderate ethanol consumption is associated with oxidative damage to heart mitochondria. and fibronectin deposition. These oxidative and ultrastuctural changes may be assumed as basic alterations in the development of alcoholic cardiomyopathy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:38:17