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Titolo:
Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white women
Autore:
Reiner, AP; Schwartz, SM; Frank, MB; Longstreth, WT; Hindorff, LA; Teramura, G; Rosendaal, FR; Gaur, LK; Psaty, BM; Siscovick, DS;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Washington, Dept Neurol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Neurol, Seattle, WA 98195 USA Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Hlth Serv, Seattle, WA 98195 USA Univ Washington, Dept Microbiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Microbiol, Seattle, WA 98195 USA Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Hlth Res Unit, Seattle, WA 98195 USA Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA Leiden Univ, Med Ctr, Ctr Hemostasis & Thrombosis Res, Leiden, NetherlandsLeiden Univ Leiden Netherlands is & Thrombosis Res, Leiden, Netherlands Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands Leiden Univ Leiden Netherlands Dept Clin Epidemiol, Leiden, Netherlands
Titolo Testata:
STROKE
fascicolo: 11, volume: 32, anno: 2001,
pagine: 2580 - 2585
SICI:
0039-2499(200111)32:11<2580:POCFXS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; A-SUBUNIT; SUBARACHNOID HEMORRHAGE; MYOCARDIAL-INFARCTION; CIGARETTE-SMOKING; FOLLOW-UP; GENE; ASSOCIATION; MECHANISM; ANTIGEN;
Keywords:
factor XIII; hemorrhagic stroke; plasminogen activator inhibitor-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Reiner, AP 7546 24th Ave NE, Seattle, WA 98115 USA 7546 24th Ave NE Seattle WA USA 98115 E, Seattle, WA 98115 USA
Citazione:
A.P. Reiner et al., "Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white women", STROKE, 32(11), 2001, pp. 2580-2585

Abstract

Background and Purpose-Although family studies have suggested a genetic influence on hemorrhagic stroke, the underlying genetic risk factors remain poorly defined. Coagulation factor XIII, which is involved in hemostasis, fibrinolysis, vascular remodeling, and tissue repair, represents a candidate gene for hemorrhagic stroke. We assessed the potential role of 3 factor XIII subunit A coding-sequence polymorphisms, along with a promoter polymorphism of plasminogen activator inhibitor-1 (PAI-1, which is also involved in fibrin stabilization and vascular remodeling), in young white women with hemorrhagic stroke. Methods-Genotype analysis for factor XIII subunit A Val34Leu, Tyr204Phe, and Pro564Leu and for PAI-1 -675 4G/5G was performed in a population-based case-control study of 42 white women aged < 45 years with nonfatal hemorrhagic stroke and 345 demographically similar control subjects. Results-Compared with the respective homozygous wild-type genotypes, the Tyr204/Phe204 genotypes (age-adjusted odds ratio [OR] 2.9, 95% 95% CI 1.1 to7.5) and the Leu564/Leu564 genotype (OR 4.3, 95% CI 1.4 to 13.7) were eachassociated with an increased risk of nonfatal hemorrhagic stroke. The riskestimate associated with the Phe204 variant was highest in women with subarachnoid hemorrhage and in nonsmokers, whereas the risk estimate of the Leu564/Leu564 genotype was highest in women with intracerebral hemorrhage and in smokers. Women who carried either the Phe204 allele or the Leu564/Leu564genotype in combination with the PAI-I 5G/5G genotype had a nearly 20-foldincreased risk of hemorrhagic stroke (OR 18.9, 95% Cl 3.8 to 95.1). Conclusions-Our findings suggest that the Phe204 and Leu564 variants of coagulation factor XIII may be markers, for genetic susceptibility to hemorrhagic stroke in women aged < 45 years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 11:55:56