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Titolo:
Lack of evidence for an association between neurofibromatosis type I and intracranial aneurysms - Autopsy study and review of the literature
Autore:
Conway, JE; Hutchins, GM; Tamargo, RJ;
Indirizzi:
Johns Hopkins Med Inst, Div Cerebrovasc Neurosurg, Dept Neurosurg, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 rg, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA Johns HopkinsMed Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA
Titolo Testata:
STROKE
fascicolo: 11, volume: 32, anno: 2001,
pagine: 2481 - 2485
SICI:
0039-2499(200111)32:11<2481:LOEFAA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
VON RECKLINGHAUSENS DISEASE; ARTERIAL OCCLUSIVE DISEASE; VONRECKLINGHAUSEN NEUROFIBROMATOSIS; CEREBRAL ANEURYSMS; GENE-PRODUCT; FUSIFORM ANEURYSM; FOLLOW-UP; IDENTIFICATION; MANAGEMENT; EXPRESSION;
Keywords:
aneurysm; autopsy; neurofibromatosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Tamargo, RJ Johns Hopkins Univ Hosp, Dept Neurosurg, Div Cerebrovasc Neurosurg, Meyer 7-113,600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Univ Hosp Meyer 7-113,600 N Wolfe St Baltimore MD USA 21287
Citazione:
J.E. Conway et al., "Lack of evidence for an association between neurofibromatosis type I and intracranial aneurysms - Autopsy study and review of the literature", STROKE, 32(11), 2001, pp. 2481-2485

Abstract

Background and Purpose-Neurofibromatosis type I (NFI) is an autosomal dominant, hereditary, neurocutaneous syndrome purported to be associated with intracranial aneurysms. To study the relationship between NFI and intracranial aneurysms, we have analyzed all intracranial autopsies of NFI patients performed at our institution from 1889 to 1999 and analyzed all intracranialaneurysm cases at our institution from 1990 to 1999 in an attempt to identify patients with NFI. In addition, we have reviewed published clinical series of NF1 patients. Methods-The autopsy database at our institution, which contains 50 000 cases from 1889 to 1999, was searched to identify NF1 patients, and the results of these autopsies were reviewed. The prevalence of intracranial aneurysms in these NFI patients was compared with the prevalence of intracranial aneurysms in our hospital's autopsy population and with the published prevalence of intracranial aneurysms in the general population. To identify patients with intracranial aneurysms and NFI, our institution's intracranial aneurysm database was searched for patients with clinical manifestations of NFl. Published clinical series of NF1 patients were identified through searches of the literature. Results-None of the 25 autopsy patients with NF1 had an intracranial aneurysm. None of the 925 patients treated for intracranial aneurysms were affected by NFl. A review of the literature identified 8 comprehensive clinical studies, all of which failed to document any relationship between NFI and intracranial aneurysms. Conclusions-The autopsy prevalence of no NFI patients with intracranial aneurysms out of 25 is not different from the prevalence of intracranial aneurysms in the general autopsy population. In addition, no patients treated for intracranial aneurysms at this institution had NFI. These findings are supported by the observation that an association between NFI and intracranial aneurysms has never been identified in 8 large clinical studies of NFI patients. We conclude that there is a lack of evidence for any association between NF1 and intracranial aneurysms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 00:41:21