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Titolo:
The value of positron emission tomography (PET) for therapeutic managementin patients with cancer of unknown primary (CUP)
Autore:
Rades, D; Kuhnel, G; Wildfang, I; Borner, AR; Knapp, W; Karstens, JH;
Indirizzi:
Hannover Med Sch, Abt Strahlentherapie & Spezielle Onkol, Hannover, Germany Hannover Med Sch Hannover Germany & Spezielle Onkol, Hannover, Germany Forschungszentrum Rossendorf, PET Zentrum, Dresden, Germany Forschungszentrum Rossendorf Dresden Germany Zentrum, Dresden, Germany Hannover Med Sch, Abt Nukl Med, Hannover, Germany Hannover Med Sch Hannover Germany Sch, Abt Nukl Med, Hannover, Germany
Titolo Testata:
STRAHLENTHERAPIE UND ONKOLOGIE
fascicolo: 10, volume: 177, anno: 2001,
pagine: 525 - 529
SICI:
0179-7158(200110)177:10<525:TVOPET>2.0.ZU;2-A
Fonte:
ISI
Lingua:
GER
Keywords:
cancer of unknown primary (CUP); positron emission tomography (PET); therapeutic strategies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Rades, D Univ Hamburg, Krankenhaus Eppendorf, Abt Strahlentherapie & Radioonkol, Martinistr 52, D-20246 Hamburg, Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20246 burg, Germany
Citazione:
D. Rades et al., "The value of positron emission tomography (PET) for therapeutic managementin patients with cancer of unknown primary (CUP)", STRAH ONKOL, 177(10), 2001, pp. 525-529

Abstract

Background: In patients with cancer of unknown primary median survival forLocalized disease is 20, for disseminated disease 7 months. After diagnostic procedures including MRI or endoscopy, the primary tumor is detected in Less than 25%. In the study presented here the value of PET for detection of the primary tumor and a possible dissemination has been investigated and related to therapeutic regimens. Patients and Methods: Between May 1998 and February 2001 a total of 52 patients with CUP syndrome, 18 females and 34 males, have been included. At first diagnosis, stage of disease was localized in 43 patients (35 lymphonodal, eight visceral), and disseminated in nine patients (Table 1). After a median of seven (range three to eleven) diagnostic procedures without detection of the primary tumor (Table 2) PET with fluorine-18-fluorodeoxyglucose was performed. Results: Due to the PET result a primary tumor was suggested in 31/52 patients (60%), and confirmed in 21/52 patients (40%). In 16/43 patients (37%) with initially (before PET) Localized disease dissemination was detected byPET only, despite various preceding diagnostic procedures (Figure 1). Overall, in 33/52 patients (63%) the PET result had major impact on selection of an individual treatment (Table 3), in case of initially localized diseasein 30/43 patients (70%). Conclusion: In patients with CUP the PET result is not only of great valuefor detection of the primary tumor, but in case of initially localized disease also for diagnosis of a possible dissemination. The PET result often has relevant influence on therapeutic management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 07:39:50