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Titolo:
Urine specific gravity and water hardness in relation to urolithiasis in persons with spinal cord injury
Autore:
Chen, Y; Roseman, JM; Funkhouser, E; DeVivo, MJ;
Indirizzi:
Univ Alabama, Dept Phys Med & Rehabil, Birmingham, AL USA Univ Alabama Birmingham AL USA pt Phys Med & Rehabil, Birmingham, AL USA Univ Alabama, Dept Epidemiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Epidemiol, Birmingham, AL 35294 USA
Titolo Testata:
SPINAL CORD
fascicolo: 11, volume: 39, anno: 2001,
pagine: 571 - 576
SICI:
1362-4393(200111)39:11<571:USGAWH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
KIDNEY-STONES; RISK-FACTORS; CALCIUM; MANAGEMENT; DIETARY; CALCULI; DISEASE;
Keywords:
spinal cord injury; calculi; specific gravity; hardness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, Y SRC 506,619 19th St S, Birmingham, AL 35249 USA SRC 506,619 19th St S Birmingham AL USA 35249 ngham, AL 35249 USA
Citazione:
Y. Chen et al., "Urine specific gravity and water hardness in relation to urolithiasis in persons with spinal cord injury", SPINAL CORD, 39(11), 2001, pp. 571-576

Abstract

Study design: A matched case-control study. Objectives: To clarify the influence of urine specific gravity and drinking water quality on the formation of urinary stones in persons with spinal cord injury (SCI). Setting: A rehabilitation center within a university hospital. Methods: Between 1992 and 1998, 63 stone cases (31 kidney, 27 bladder, andfive both) and 289 age-duration-matched controls were recruited from a cohort of SCI patients enrolled in an on-going longitudinal study. Data on urine specific gravity and other characteristics of study participants were retrieved from the database and medical charts. Community water supply information was provided by the Alabama Department of Environmental Management. Multivariable conditional logistic regression analysis was performed to evaluate the association with stone formation. Results: SCI individuals who had urinary stones were more likely than control subjects to use indwelling catheters and have decreased renal function. The occurrence of stones was not significantly related to gender, race, severity of injury, urinary tract infection, nor urine pH. After controlling for the potential confounding from other factors, a continuously increasingstone occurrence with increasing specific gravity was observed (P=0.05); this association was stronger for kidney (odds Ratio [OR]= 1.8 per 0.010 g/cm(3)) versus bladder stones (OR 1.2) and for recurrent (OR= 2.0) versus first stones (OR= 1.5). Increased water hardness was not significantly associated with a decreased stone occurrence. Conclusions: Study results suggest that maintaining urine specific gravitybelow a certain level might reduce the occurrence of urinary stones. This could be easily achieved by using a dipstick for self-feedback along with appropriate fluid intake. For persons with SCI who are at an increased risk of a devastating stone disease, this prophylactic approach could be very cost-effective; however, this requires further confirmation.

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Documento generato il 05/12/20 alle ore 13:42:46