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Titolo:
EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes
Autore:
Zimber-Strobl, U; Strobl, LJ;
Indirizzi:
Univ Cologne, Inst Genet, D-50931 Cologne, Germany Univ Cologne Cologne Germany D-50931 nst Genet, D-50931 Cologne, Germany
Titolo Testata:
SEMINARS IN CANCER BIOLOGY
fascicolo: 6, volume: 11, anno: 2001,
pagine: 423 - 434
SICI:
1044-579X(200112)11:6<423:EANSIE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RBP-J-KAPPA; LATENT MEMBRANE-PROTEIN; NUCLEAR-PROTEIN-2 ACIDIC DOMAIN; RESPONSIVE CIS-ELEMENT; DNA-BINDING PROTEIN; NUCLEAR ANTIGEN-2; NEOPLASTIC TRANSFORMATION; GROWTH TRANSFORMATION; INTRACELLULAR DOMAIN; HISTONE DEACETYLASE;
Keywords:
Epstein-Barr virus; B lymphocytes; EBNA2; Notch; RBP-J;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
143
Recensione:
Indirizzi per estratti:
Indirizzo: Zimber-Strobl, U Univ Cologne, Inst Genet, Weyertal 121, D-50931 Cologne, Germany Univ Cologne Weyertal 121 Cologne Germany D-50931 ermany
Citazione:
U. Zimber-Strobl e L.J. Strobl, "EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes", SEM CANC B, 11(6), 2001, pp. 423-434

Abstract

Epstein-Barr virus (EBV) has the ability to immortalize B cells. A viral key protein for immortalization is the transactivator EBNA2 that controls expression of several viral and cellular genes. EBNA2 is tethered to promoters by interacting with the cellular repressor RBP-J. This resembles the physiological activation of RBP RBP-J-repressed promoters by activated Notch receptors (Notch-IC). Since EBNA2 and Notch-IC have been shown to be partially interchangeable in regard to activation of target genes in B cell lines and modulation of differentiation processes it is conceivable that EBNA2 is a biological equivalent of an activated Notch receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:55:22