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Titolo:
Signalling events regulating lymphoid growth and survival
Autore:
Brennan, P;
Indirizzi:
Infect & Immun, Cardiff CF14 4XX, S Glam, Wales Infect & Immun Cardiff S Glam Wales CF14 4XX diff CF14 4XX, S Glam, Wales
Titolo Testata:
SEMINARS IN CANCER BIOLOGY
fascicolo: 6, volume: 11, anno: 2001,
pagine: 415 - 421
SICI:
1044-579X(200112)11:6<415:SERLGA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; KINASE-B ACTIVATION; CYCLIN D2; CELL-LINES; KAPPA-B; C-MYC; PHOSPHATIDYLINOSITOL 3-KINASE; LATENT MEMBRANE-PROTEIN-1; BAD PHOSPHORYLATION; EPITHELIAL-CELLS;
Keywords:
Epstein-Barr virus; lymphoma; phosphatidylinositol 3-kinase; PKB; STAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Brennan, P Infect & Immun, Tenovus Bldg,Heath Pk, Cardiff CF14 4XX, S Glam, Wales Infect & Immun Tenovus Bldg,Heath Pk Cardiff S Glam Wales CF14 4XX
Citazione:
P. Brennan, "Signalling events regulating lymphoid growth and survival", SEM CANC B, 11(6), 2001, pp. 415-421

Abstract

Epstein-Barr virus (EBV) uses many different strategies to induce lymphocyte proliferation and survival. In the different states of EBV infection andlatency, several genes play specific roles in the induction of cell growthand cell survival proteins. EBNA2A, EBNA-LP and EBNA3C all modulate early events in the G1 phase of the cell cycle. Furthermore, interleukin-6 and interleukin-10, which are induced following EBV infection, appear to be important for growth. They activate signalling pathways that have been shown to link directly to proliferation. Latent membrane protein I (LMP1) induces a number of anti-apoptotic proteins via NF-kappaB, and LMP2A also appears to contribute to lymphocyte survival. This paper describes some of the many cellular pathways modulated by EBV that interact with the signalling machinery and th us make lymphocytes survive and grow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 05:20:46