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Titolo:
Identification of EBV transforming genes by recombinant EBV technology
Autore:
Izumi, KM;
Indirizzi:
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 robiol & Mol Genet, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Dept Med, Boston, MA 02115 USA
Titolo Testata:
SEMINARS IN CANCER BIOLOGY
fascicolo: 6, volume: 11, anno: 2001,
pagine: 407 - 414
SICI:
1044-579X(200112)11:6<407:IOETGB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; LYMPHOCYTE GROWTH TRANSFORMATION; NF-KAPPA-B; LATENT MEMBRANE-PROTEIN-1 ENGAGES; 2ND-SITE HOMOLOGOUS RECOMBINATION; CELL-LINE; MEMBRANE PROTEIN-1; NUCLEAR PROTEIN-2; KILOBASE PAIRS; INFECTION;
Keywords:
genetics; herpes virus; lymphocyte; recombinant; transformation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Izumi, KM Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, 857 Channing Lab,181 Longwood Ave, Boston, MA 02115 USA Harvard Univ 857 Channing Lab,181 Longwood Ave Boston MA USA 02115
Citazione:
K.M. Izumi, "Identification of EBV transforming genes by recombinant EBV technology", SEM CANC B, 11(6), 2001, pp. 407-414

Abstract

Epstein-Barr virus (EBV) is able to infect primary B-lymphocytes but usually does not proceed to replicate more virions. Instead, EBV persists as an incomplete virus and expresses 12 gene products that transform the growth of these cells into continuously proliferating lymphoblastoid cell lines. Because EBV is associated with several human malignancies, there is intense interest in delineating the molecular functions of these EBV gene products in transformation. This review focuses on the recombinant EBV technologies that have been developed to introduce specific mutations into EBV and test the functions of these EBV genes in primary B-lymphocyte growth transformation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:23:59