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Titolo:
Serum cystatin C is a better marker for preeclampsia than serum creatinineor serum urate
Autore:
Strevens, H; Wide-Swensson, D; Grubb, A;
Indirizzi:
Univ Lund Hosp, Dept Obstet & Gynecol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 tet & Gynecol, SE-22185 Lund, Sweden Univ Lund Hosp, Dept Clin Chem, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 ept Clin Chem, SE-22185 Lund, Sweden
Titolo Testata:
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
fascicolo: 7, volume: 61, anno: 2001,
pagine: 575 - 580
SICI:
0036-5513(2001)61:7<575:SCCIAB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; RENAL-FUNCTION; SENSITIVE MARKER; REFERENCE VALUES; PRE-ECLAMPSIA; CLEARANCE; CHILDREN; IMMUNOASSAY; GFR;
Keywords:
pregnancy; reference values; renal function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Strevens, H Univ Lund Hosp, Dept Obstet & Gynecol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 l, SE-22185 Lund, Sweden
Citazione:
H. Strevens et al., "Serum cystatin C is a better marker for preeclampsia than serum creatinineor serum urate", SC J CL INV, 61(7), 2001, pp. 575-580

Abstract

Altered renal function is an essential component of the pathophysiologicalprocess in preeclampsia. The kidneys play a significant part in the turnover of most low molecular weight Substances such as creatinine, urate and cystatin C. The present work was undertaken to investigate if the serum levels of these components are altered in characteristic ways in preeclampsia, and can be used to assist in the diagnosis of this condition. The serum levels were therefore determined in samples from 100 healthy women at term as well as in 45 samples of patients with preeclampsia (diastolic blood pressure > 90 mmHg; urinary albumin excretion > 300 mg L-1). The levels of all three components were significantly higher in samples from preeclamptic patients with the mean +/- SD being 1.55 +/-0.29 vs. 1.05 +/-0.19mg L-1 for cystatin C, 70 +/- 23 vs. 56 +/-9.7 mu mol L-1 for creatinine, and 413 +/- 128 vs, 305 +/- 61 mu mol L-1 for urate. Receiver operating characteristic analysis demonstrated that the serum level of cystatin C had a superior diagnostic accuracy for preeclampsia compared to those of serum urate and creatinine and that the diagnostic accuracy of serum mate was better than that of serum creatinine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:43:35