Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cholecystokinin and panic disorder: Past and future clinical research strategies
Autore:
Bradwejn, J; Koszycki, D;
Indirizzi:
Royal Ottawa Hosp, Ottawa, ON K1Z 7K4, Canada Royal Ottawa Hosp Ottawa ONCanada K1Z 7K4 sp, Ottawa, ON K1Z 7K4, Canada Univ Ottawa, Dept Psychiat, Ottawa, ON K1N 6N5, Canada Univ Ottawa OttawaON Canada K1N 6N5 Psychiat, Ottawa, ON K1N 6N5, Canada
Titolo Testata:
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
, volume: 61, anno: 2001, supplemento:, 234
pagine: 19 - 27
SICI:
0036-5513(2001)61:<19:CAPDPA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; BRAIN METABOLIC CHANGES; HEALTHY-VOLUNTEERS; BENZODIAZEPINE RECEPTOR; TETRAPEPTIDE CHALLENGE; BEHAVIORAL FINDINGS; INDUCED ACTIVATION; NERVOUS-SYSTEM; SOCIAL PHOBIA; B ANTAGONIST;
Keywords:
anxiety; panic attacks; peptides; CCK; CCK-2; neurobiology; psychiatry; psychology; genetics; panicogens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Bradwejn, J Royal Ottawa Hosp, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada Royal Ottawa Hosp 1145 Carling Ave Ottawa ON Canada K1Z 7K4 da
Citazione:
J. Bradwejn e D. Koszycki, "Cholecystokinin and panic disorder: Past and future clinical research strategies", SC J CL INV, 61, 2001, pp. 19-27

Abstract

The involvement of cholecystokinin (CCK) in human anxiety is well documented. Exogenous administration of CCK-2 receptor agonists, such as cholecystokinin-tetrapeptide and pentagastrin, provoke panic attacks in man. Patientswith panic disorder (PD) are hypersensitive. to CCK-2 receptor stimulationcompared to healthy volunteers and patients with other anxiety disorders, and they differ from healthy subjects in CCK metabolism and genetic characteristics of the CCK-2 receptor system. This article reviews the corpus of work supporting the role of CCK in anxiety and suggests three research approaches which can further enhance our understanding of the CCK-2 system in PD. These approaches include: i) searching for a specific anomaly of the CCK-2 receptor system, ii) establishing a relationship between CCK-2 receptor polymorphism and vulnerability to pharmacologically-induced or spontaneous panic attacks, and iii) evaluating the therapeutic efficacy of CCK-2 receptor antagonists which possess adequate pharmacokinetic properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 01:52:04