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Titolo:
Genetic association between the apolipoprotein E (APOE) gene and differentforms of Alzheimer's disease
Autore:
Korovaitseva, GI; Sherbatich, TV; Selezneva, NV; Gavrilova, SI; Golimbet, VE; Voskresenskaya, NI; Rogaev, EI;
Indirizzi:
Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 113152, Russia Russian Acad Med Sci Moscow Russia 113152 Res Ctr, Moscow 113152, Russia Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia Russian Acad Sci Moscow Russia 123182 t Mol Genet, Moscow 123182, Russia
Titolo Testata:
RUSSIAN JOURNAL OF GENETICS
fascicolo: 4, volume: 37, anno: 2001,
pagine: 422 - 427
SICI:
1022-7954(200104)37:4<422:GABTAE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOFORM-SPECIFIC INTERACTIONS; EARLY-ONSET; MISSENSE MUTATIONS; AFRICAN-AMERICANS; TYPE-4 ALLELE; PROTEIN; RISK; POLYMORPHISM; POPULATION; DEMENTIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Korovaitseva, GI Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 113152,Russia Russian Acad Med Sci Moscow Russia 113152 13152, Russia
Citazione:
G.I. Korovaitseva et al., "Genetic association between the apolipoprotein E (APOE) gene and differentforms of Alzheimer's disease", RUSS J GEN, 37(4), 2001, pp. 422-427

Abstract

Allele epsilon4 of the apolipoprotein E (APOE) gene is associated with higher risk for family or sporadic Alzheimer's disease (AD) in many, though not all, ethnic groups. The APOE allele and genotype frequency distributions were evaluated in 207 AD patients without vascular disorders, 62 AD patients with vascular disorders (combined AD), and 206 control individuals (ethnic Russians from the Russian population). The frequency of allele epsilon4 in patients with early-onset and late-onset AD was three times higher than in controls (P<0.000001). The increase in the frequency of <epsilon>4 in mixed dementia cases over controls was somewhat less but still significant (P=0.0019). Relative risk of AD in carriers of allele epsilon4 was five times higher than in carriers of alleles epsilon2 and epsilon3 (P<0.000001). Allele <epsilon>2 showed evidence of a protective effect in the early-onset AD group (P=0.015). These results suggest that APOE allele epsilon4 is a universal factor of early-onset, late-onset, and combined AD in ethnic Russians from Russia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:13:31