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Titolo:
Mechanisms of genetic instability in mollicutes (mycoplasmas)
Autore:
Momynaliev, KT; Govorun, VM;
Indirizzi:
Res Inst Physicochem Med, Moscow 118128, Russia Res Inst Physicochem Med Moscow Russia 118128 Med, Moscow 118128, Russia
Titolo Testata:
RUSSIAN JOURNAL OF GENETICS
fascicolo: 9, volume: 37, anno: 2001,
pagine: 979 - 992
SICI:
1022-7954(200109)37:9<979:MOGIIM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREQUENCY PHASE VARIATION; MYCOIDES SUBSP MYCOIDES; ANTIGENIC VARIATION; MOLECULAR-BASIS; UREAPLASMA-UREALYTICUM; SURFACE LIPOPROTEIN; INSERTION ELEMENT; SEQUENCE-ANALYSIS; SPONTANEOUS MUTATION; REPLICATION ORIGIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Momynaliev, KT Res Inst Physicochem Med, Moscow 118128, Russia Res Inst Physicochem Med Moscow Russia 118128 128, Russia
Citazione:
K.T. Momynaliev e V.M. Govorun, "Mechanisms of genetic instability in mollicutes (mycoplasmas)", RUSS J GEN, 37(9), 2001, pp. 979-992

Abstract

Mollicutes are unique microorganisms characterized by a great extent for the reduction in genetic material, which retained the capability of independent division on acellular nutrient media. Phenotypically mycoplasmas differed from other bacteria by their small size and lack of a cell wall (mollis,soft; cutis, skin). High dependence on metabolism components utilized in the cultivation medium and high metabolic plasticity due to the absence of many genome regulatory elements make mycoplasmas perfect parasites for cellsof the eukaryotic origin. The ability of these microorganisms to pass through host cells and their assumed participation in AIDS activation facilitate the study of mycoplasma pathogenesis. Another important feature of mycoplasmas, which is expressed during their interaction with a macroorganism, istheir ability to escape from the immune response of a host due to surface antigen variation. These adaptation capacities of mycoplasmas ensuring their life in various biological niches, given a limited genome and the direct metabolic dependence on an environment, cannot be adequately explained at present. In this review, we attempted to collect and systematize data that contribute to our understanding of the important feature of mycoplasmas, genetic instability, which may underlie many of their adaptive responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:39:43