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Titolo:
Dengue fever and dengue haemorrhagic fever: challenges of controlling an enemy still at large
Autore:
Kurane, I; Takasaki, T;
Indirizzi:
Natl Inst Infect Dis, Dept Virol 1, Shinjuku Ku, Tokyo 1628640, Japan NatlInst Infect Dis Tokyo Japan 1628640 injuku Ku, Tokyo 1628640, Japan
Titolo Testata:
REVIEWS IN MEDICAL VIROLOGY
fascicolo: 5, volume: 11, anno: 2001,
pagine: 301 - 311
SICI:
1052-9276(200109/10)11:5<301:DFADHF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; HEMORRHAGIC-FEVER; VIRUS-INFECTION; DISEASE SEVERITY; NEUROBLASTOMA-CELLS; MOLECULAR EVOLUTION; CYTOKINE PRODUCTION; ENDOTHELIAL-CELLS; INTERFERON-GAMMA; HEPARAN-SULFATE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Kurane, I Natl Inst Infect Dis, Dept Virol 1, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628640, Japan Natl Inst Infect Dis 1-23-1 Toyama Tokyo Japan 1628640 0, Japan
Citazione:
I. Kurane e T. Takasaki, "Dengue fever and dengue haemorrhagic fever: challenges of controlling an enemy still at large", REV MED VIR, 11(5), 2001, pp. 301-311

Abstract

Dengue virus infections are a serious cause of morbidity and mortality in most tropical and subtropical areas of the world: mainly Southeast and South Asia, Central and South America, and the Caribbean. Understanding the pathogenesis of dengue haemorrhagic fever (DHF), the severe form of dengue illness, is a very important and challenging research subject. Viral virulenceand immune responses have been considered as two major factors responsiblefor the pathogenesis. Virological studies are attempting to define the molecular basis of viral virulence. The immunopathological mechanisms appear to include a complex series of immune responses. A rapid increase in the levels of cytokines and chemical mediators apparently plays a key role in inducing plasma leakage, shock and haemorrhagic manifestations. It is likely that the entire process is initiated by infection with a so-called virulent dengue virus, often with the help of enhancing antibodies in secondary infection, and then triggered by rapidly elevated cytokines and chemical mediators produced by intense immune activation. However, understanding of the DHFpathogenesis is not complete. We still have a long way to go. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:39:18