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Titolo:
Surfactant alteration and replacement in acute respiratory distress syndrome
Autore:
Gunther, A; Ruppert, C; Schmidt, R; Markart, P; Grimminger, F; Walmrath, D; Seeger, W;
Indirizzi:
Univ Giessen, Dept Internal Med, D-35390 Giessen, Germany Univ Giessen Giessen Germany D-35390 ernal Med, D-35390 Giessen, Germany
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 6, volume: 2, anno: 2001,
pagine: 353 - NIL_2
SICI:
1465-993X(2001)2:6<353:SAARIA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LUNG INJURY; PULMONARY SURFACTANT; IN-VITRO; SP-A; FIBROBLAST PROLIFERATION; ALVEOLAR SURFACTANT; PORCINE SURFACTANT; SEVERE PNEUMONIA; FIBRIN TURNOVER; PLASMA-PROTEINS;
Keywords:
acute lung injury; ARDS; pulmonary surfactant; surfactant replacement;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Gunther, A Med Klin 2, Klin Str 36, D-35385 Giessen, Germany Med Klin 2 Klin Str 36 Giessen Germany D-35385 iessen, Germany
Citazione:
A. Gunther et al., "Surfactant alteration and replacement in acute respiratory distress syndrome", RESPIR RES, 2(6), 2001, pp. 353-NIL_2

Abstract

The acute respiratory distress syndrome (ARDS) is a frequent, life-threatening disease in which a marked increase in alveolar surface tension has been repeatedly observed. It is caused by factors including a lack of surface-active compounds, changes in the phospholipid, fatty acid, neutral lipid, and surfactant apoprotein composition, imbalance of the extracellular surfactant subtype distribution, inhibition of surfactant function by plasma protein leakage, incorporation of surfactant phospholipids and apoproteins intopolymerizing fibrin, and damage/inhibition of surfactant compounds by inflammatory mediators. There is now good evidence that these surfactant abnormalities promote alveolar instability and collapse and, consequently, loss of compliance and the profound gas exchange abnormalities seen in ARDS. An acute improvement of gas exchange properties together with a far-reaching restoration of surfactant properties was encountered in recently performed pilot studies. Here we summarize what is known about the kind and severity ofsurfactant changes occuring in ARDS, the contribution of these changes to lung failure, and the role of surfactant administration for therapy of ARDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:06:06