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Titolo:
Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease
Autore:
Brown, LM; Rannels, SR; Rannels, DE;
Indirizzi:
Penn State Univ, Coll Med H166, Dept Cellular & Mol Physiol C4600D, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 hysiol C4600D, Hershey, PA 17033 USA
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 6, volume: 2, anno: 2001,
pagine: 340 - 347
SICI:
1465-993X(2001)2:6<340:IOPCLG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILATERAL PNEUMONECTOMY; PARTIAL-HEPATECTOMY; ADAPTIVE RESPONSE; REGENERATING LUNG; SOMATOMEDIN-C; RAT LUNG; DOGS; RECURRENCE; HORMONE; MICE;
Keywords:
biomechanical signaling; cellular differentiation; lung growth; metastatic tumors; pulmonary carcinogenesis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Rannels, DE Penn State Univ, Coll Med H166, Dept Cellular & Mol Physiol C4600D, 500 Univ Dr, Hershey, PA 17033 USA Penn State Univ 500 Univ Dr Hershey PA USA 17033 PA 17033 USA
Citazione:
L.M. Brown et al., "Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease", RESPIR RES, 2(6), 2001, pp. 340-347

Abstract

In a number of species, partial pneumonectomy initiates hormonally regulated compensatory growth of the remaining lung lobes that restores normal mass, structure and function. Compensation is qualitatively similar across species, but differs with gender, age and hormonal status. Although the biology of response is best characterized in rats, dogs have proven valuable in defining post-operative physiological adaptations. Most recently, mice were recognized to offer unique opportunities to explore the genetic basis of the response, as well as to evaluate associated detrimental effects of pathophysiological significance in animals exposed to carcinogens. The pneumonectomy model thus offers powerful insight concerning adaptive organ growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:51:09