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Titolo:
Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses
Autore:
Tantisira, KG; Weiss, ST;
Indirizzi:
Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA Brigham & WomensHosp Boston MA USA 02115 nning Lab, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 6, volume: 2, anno: 2001,
pagine: 324 - 327
SICI:
1465-993X(2001)2:6<324:CIAAAT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAY-FEVER; RESPIRATORY ILLNESS; MATERNAL SMOKING; ATOPY; RISK; CHILDREN; LIFE; SENSITIZATION; EXPOSURE; WHEEZE;
Keywords:
asthma; child; fetal programming; gene by environment; infection;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tantisira, KG Brigham & Womens Hosp, Channing Lab, 181 Longwood Ave, Boston, MA 02115 USA Brigham & Womens Hosp 181 Longwood Ave Boston MA USA 02115 A
Citazione:
K.G. Tantisira e S.T. Weiss, "Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses", RESPIR RES, 2(6), 2001, pp. 324-327

Abstract

The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 immunophenotype, thereby predisposing the child to atopic disease. While multiple studies support the hygiene hypothesis in asthma ontogeny, the evidence remains inconclusive; multiple other environmental exposures in early childhood also alter predisposition to asthma. Moreover, the current paradigm for asthma development extends far beyond simple childhood environmental exposures to include fetal development, genetic predisposition, and interactions of the developmental state and genetics with the environment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 17:21:55