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Titolo:
Distribution of vascular endothelial growth factor (VEGF) and its binding sites at the maternal-fetal interface during gestation in pigs
Autore:
Charnock-Jones, DS; Clark, DE; Licence, D; Day, K; Wooding, FBP; Smith, SK;
Indirizzi:
Univ Cambridge, Rosie Hosp, Dept Obstet & Gynecol, Reprod Mol Res Grp, Cambridge CB2 2SW, England Univ Cambridge Cambridge England CB2 2SW Grp, Cambridge CB2 2SW, England Babraham Inst, Cambridge CB2 4AQ, England Babraham Inst Cambridge England CB2 4AQ Inst, Cambridge CB2 4AQ, England
Titolo Testata:
REPRODUCTION
fascicolo: 5, volume: 122, anno: 2001,
pagine: 753 - 760
SICI:
1470-1626(200111)122:5<753:DOVEGF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PLACENTA; PERMEABILITY FACTOR; INITIAL VASCULARIZATION; CORROSION CASTS; TYROSINE KINASE; MESSENGER-RNA; FACTOR GENE; EXPRESSION; IDENTIFICATION; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Charnock-Jones, DS Univ Cambridge, Rosie Hosp, Dept Obstet & Gynecol, Reprod Mol Res Grp, Cambridge CB2 2SW, England Univ Cambridge Cambridge England CB2 2SW 2SW, England
Citazione:
D.S. Charnock-Jones et al., "Distribution of vascular endothelial growth factor (VEGF) and its binding sites at the maternal-fetal interface during gestation in pigs", REPRODUCT, 122(5), 2001, pp. 753-760

Abstract

Pigs show epitheliochorial placentation, in which the maternal uterine epithelium and the fetal trophectoderm become closely apposed. There is no invasion of trophoblast into the maternal tissue, and nutrient and waste exchange take place across two epithelial layers beneath which a complex networkof capillaries forms. Later in gestation, the epithelial cells become indented by blood vessels, which greatly reduces the distance for diffusion between the two circulatory systems. Vascular endothelial growth factor is a secreted homodimeric angiogenic growth factor that is involved in physiological and pathological angiogenesis. Its receptors are generally restricted to endothelial cells. Ligand binding, in situ hybridization and immunohistochemistry were carried out in pig placenta throughout gestation to investigate the possible role of vascular endothelial growth factor and its receptors in non-invasive placentation. In situ hybridization and immunohistochemistry revealed that mRNA and immunoreactivity for vascular endothelial growthfactor were localized in both maternal and fetal epithelial cells at the maternal-fetal interface and over the maternal glands, although the signal was generally weaker in the maternal glands. Ligand binding was used to localize for vascular endothelial growth factor receptors; no binding was observed over the maternal glands, but very strong binding was localized to the endometrial blood vessels. At the interface between maternal and fetal tissue, a similar pattern was observed whereby the numerous small capillaries at the bases of the two apposed epithelia bound vascular endothelial growth factor specifically. It is concluded that vascular endothelial growth factor produced by the maternal and fetal epithelial layers promotes the growth of capillaries locally, which would facilitate the development of two vascular networks for the efficient transfer of nutrients and waste products.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:41:57