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Titolo:
Thrombotic thrombocytopenic purpura in a case of scleroderma renal crisis treated with twice-daily therapeutic plasma exchange
Autore:
Baz, EMK; Mahfouz, RAR; Masri, AFM; Jamaleddine, GW;
Indirizzi:
Amer Univ Beirut, Med Ctr, Dept Pathol & Lab Med, Beirut, Lebanon Amer Univ Beirut Beirut Lebanon Dept Pathol & Lab Med, Beirut, Lebanon
Titolo Testata:
RENAL FAILURE
fascicolo: 5, volume: 23, anno: 2001,
pagine: 737 - 742
SICI:
0886-022X(2001)23:5<737:TTPIAC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Keywords:
scleroderma renal crisis; systemic sclerosis; thrombotic; thrombocytopenic purpura; therapeutic plasma exchange; twice-daily; intensive regimen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Baz, EMK Amer Univ Beirut, Med Ctr, Dept Pathol & Lab Med, POB 11-0236, Beirut, Lebanon Amer Univ Beirut POB 11-0236 Beirut Lebanon 36, Beirut, Lebanon
Citazione:
E.M.K. Baz et al., "Thrombotic thrombocytopenic purpura in a case of scleroderma renal crisis treated with twice-daily therapeutic plasma exchange", RENAL FAIL, 23(5), 2001, pp. 737-742

Abstract

We report the rare complication of thrombotic thrombocytopenic purpura (TTP) in an elderly patient with the uncommon scleroderma renal crisis (SRC) at the advanced age of 85 years. Initially, she was treated by standard daily one and a half plasma volume therapeutic plasma exchange (TPE), in combination with steroid therapy. Due to an unsatisfactory clinical response, shewas consequently, treated by an intensive twice-daily one and a half plasma volume TPE regimen. Although there was an increase in the platelet count,a 7-day course of the intensive regimen did not elicit further propitious laboratory test results or a clinical improvement and the patient expired secondary to the pulmonary and cardiac conditions related to SRC. Intensive TPE administration has been advocated in few specific patients who are refractory to standard daily treatment. The unfavorable outcome in this case may be attributed to the multiple complications associated with her primary disorder. In conclusion, we observed intensive twice-daily TPE to increase temporarily the platelet count, but not to be of benefit in a patient with SRC and multiple organ failure. The two TPE regimens and outcomes are compared and the pathogenesis of TTP and scleroderma are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:31:58