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Titolo:
Can recovery from depression be achieved.?
Autore:
Shelton, RC; Tomarken, AJ;
Indirizzi:
Vanderbilt Univ, Med Ctr, Nashville, TN USA Vanderbilt Univ Nashville TN USA erbilt Univ, Med Ctr, Nashville, TN USA
Titolo Testata:
PSYCHIATRIC SERVICES
fascicolo: 11, volume: 52, anno: 2001,
pagine: 1469 - 1478
SICI:
1075-2730(200111)52:11<1469:CRFDBA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; NATIONAL-COMORBIDITY-SURVEY; BEHAVIORAL-ANALYSIS SYSTEM; VENTRAL TEGMENTAL AREA; ATYPICAL DEPRESSION; MAJOR DEPRESSION; RECEPTOR SUBTYPES; AUGMENTATION STRATEGIES; EXTRACELLULAR DOPAMINE; REFRACTORY DEPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Shelton, RC 1500 21st Ave S,Suite 2200, Nashville, TN 37212 USA 1500 21stAve S,Suite 2200 Nashville TN USA 37212 N 37212 USA
Citazione:
R.C. Shelton e A.J. Tomarken, "Can recovery from depression be achieved.?", PSYCH SERV, 52(11), 2001, pp. 1469-1478

Abstract

Even though a variety of treatments are available for depression, many patients experience an incomplete response, resulting in chronic functional impairment. The authors present a therapeutic heuristic that derives, in part, from a body of research that suggests that symptoms of mood disorders canbe separated into three distinct components: somatic anxiety, which is most prominent in anxiety disorders, such as panic; anhedonia or low positive affect, which is most specific to depression; and general distress, which is present with both anxiety and depressive disorders. General distress and somatic anxiety appear to be significantly modulated by serotonin, and serotonergic drugs may exert their effects most significantly on these symptoms. On the other hand, positive affect, the dimension of reward-oriented motivation and enjoyment, appears to be most dependent on dopamine and, indirectly, norepinephrine. Thus a theoretical heuristic can be derived on the basis of the predominance of residual symptoms. Serotonergic agents would be chosen for monotherapy or augmentation for symptoms of distress. Alternatively, catecholaminergic drugs would be the first choice for anhedonia and decreased motivation.

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Documento generato il 20/01/20 alle ore 15:59:51