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Titolo:
Endothelin involvement in respiratory centre activity
Autore:
Albertini, M; Lafortuna, CL; Ciminaghi, B; Mazzola, S; Clement, MG;
Indirizzi:
Univ Milan, Fac Vet Med, Dipartimento Patol Anim Igiene & Sanita Pubbl Vet, Sez Biochim & Fisiol, I-20133 Milan, Italy Univ Milan Milan Italy I-20133 ez Biochim & Fisiol, I-20133 Milan, Italy CNR, Ist Tecnol Biomed Avanzate, I-20131 Milan, Italy CNR Milan Italy I-20131 Ist Tecnol Biomed Avanzate, I-20131 Milan, Italy
Titolo Testata:
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
fascicolo: 3, volume: 65, anno: 2001,
pagine: 157 - 163
SICI:
0952-3278(200109)65:3<157:EIIRCA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; RAT-BRAIN; ANTAGONIST BOSENTAN; RECEPTOR-BINDING; PIG; PULMONARY; EXPRESSION; MODULATION; NEURONS; HYPOXIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Albertini, M Univ Milan, Fac Vet Med, Dipartimento Patol Anim Igiene & Sanita Pubbl Vet, Sez Biochim & Fisiol, Via Celoria 10, I-20133 Milan, Italy Univ Milan Via Celoria 10 Milan Italy I-20133 3 Milan, Italy
Citazione:
M. Albertini et al., "Endothelin involvement in respiratory centre activity", PROS LEUK E, 65(3), 2001, pp. 157-163

Abstract

To evaluate the role of endothelin (ET) in respiratory homeostasis we studied the effects of the ETA and ETB receptor blocking agent bosentan on respiratory mechanics and control in seven anaesthetised spontaneously breathing pigs, for 180 min after single bolus administration (20 mg/kg i.v.). The results show that the block of ETreceptors induced a significant increase in compliance and decrease in resistance of the respiratory system, entailing a significant reduction of diaphragmatic electromyographic activity, without affecting the centroid frequency of the power spectrum. Bosentan administration induced a significant increase in tidal volume (V-T) accompanied by a significant decrease in respiratory frequency, without any significant change in pulmonary ventilation, CO2 arterial blood gas pressure or pH. Since the relationship between V-T and inspiratory time remained substantiallyconstant after bosentan administration, the changes in respiratory patternappear to be the result of an upward shift in inspiratory off-switch threshold. Both inspiratory and expiratory times during occluded breathing were increased by block of ETreceptors, suggesting also a central respiratory neuromodulator effect of ET. In conclusion the present results suggest that the block of ETreceptors in spontaneously breathing pigs exerts a role on mechanical properties of the respiratory system as well as on peripheral and central mechanisms of breathing control. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:56:49