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Titolo:
Idiopathic male infertility and androgen receptors.
Autore:
Wallerand, H; Chabannes, E; Bittard, H;
Indirizzi:
Hop St Jacques, Serv Urol, F-25030 Besancon, France Hop St Jacques Besancon France F-25030 rv Urol, F-25030 Besancon, France
Titolo Testata:
PROGRES EN UROLOGIE
fascicolo: 4, volume: 11, anno: 2001,
pagine: 610 - 620
SICI:
1166-7087(200109)11:4<610:IMIAAR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
FRE
Soggetto:
BULBAR MUSCULAR-ATROPHY; LIGAND-BINDING DOMAIN; N-TERMINAL DOMAIN; CAG REPEAT LENGTH; GENE-MUTATIONS DATABASE; PROSTATE-CANCER; GLUCOCORTICOID RECEPTOR; TRINUCLEOTIDE REPEATS; STEROID-BINDING; DNA-BINDING;
Keywords:
idiopathic male infertility; androgen receptor; ICSI;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Wallerand, H Hop St Jacques, Serv Urol, 2 Pl St Jacques, F-25030 Besancon,France Hop St Jacques 2 Pl St Jacques Besancon France F-25030 rance
Citazione:
H. Wallerand et al., "Idiopathic male infertility and androgen receptors.", PROG UROL, 11(4), 2001, pp. 610-620

Abstract

In France, 12 to 15% of couples experience procreation difficulties. A disorder of spermatogenesis (oligospermia, azoospermia), is responsible in 1/3of cases. These forms of infertility, labelled idiopathic, probably have agenetic component, like microdeletions of the Y chromosome. The normal rate of circulating androgens suggests the implication, in some cases, of an abnormality from the receptor to the androgens (RA) of these male infertilities, whose number remains to be defined. Point mutations on exons of the gene encoding the AR cannot account for all cases of infertility due to idiopathic disorders of spermatogenesis. Expansion of the number of CAG tripletsof exon 1 of the AR gene, already demonstrated in a fatal degenerative neuropathy (Kennedy's disease, in which more than 50% of patients are infertile), has been detected in these cases of idiopathic infertility and would beresponsible for AR dysfunction. The number of these triplets is also decreased in patients with androgen-dependent prostate cancer. The polymorphism,of repetition of CAG triplets would therefore be responsible for fine adjustment of the AR between excessive and insufficient function. ICSI. (Intra-Cytoplasmic Sperm Injection) is currently proposed in these cases of infertility, but the consequences of transmission of these abnormalities to the offspring are unknown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:09:42