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Titolo:
Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway
Autore:
Bi, RF; Foy, MR; Vouimba, RM; Thompson, RF; Baudry, M;
Indirizzi:
Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Program, Los Angeles, CA 90089 USA Loyola Marymount Univ, Dept Psychol, Los Angeles, CA 90045 USA Loyola Marymount Univ Los Angeles CA USA 90045 Los Angeles, CA 90045 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 23, volume: 98, anno: 2001,
pagine: 13391 - 13395
SICI:
0027-8424(20011106)98:23<13391:CCIERS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; DENDRITIC SPINE DENSITY; LONG-TERM POTENTIATION; ESTROUS-CYCLE; HIPPOCAMPAL-NEURONS; TYROSINE KINASE; SPATIAL MEMORY; DENTATE GYRUS; FEMALE RAT; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Baudry, M Univ So Calif, Neurosci Program, HNB124, Los Angeles, CA 90089 USA Univ So Calif HNB124 Los Angeles CA USA 90089 eles, CA 90089 USA
Citazione:
R.F. Bi et al., "Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway", P NAS US, 98(23), 2001, pp. 13391-13395

Abstract

Hippocampal synaptic structure and function exhibit marked variations during the estrus cycle of female rats. Estradiol activates the mitogen-activated protein (MAP) kinase pathway in numerous cell types, and MAP kinase has been shown to play a critical role in the mechanisms underlying synaptic plasticity. Here, we report that endogenous estrogen produces a tonic phosphorylation/activation of extracellular signal-regulated kinase 2 (ERK2)/MAP kinase throughout the female rat brain and an increase in tyrosine phosphorylation of NR2 subunits of N-methyl-D-aspartate (NMDA) receptors. Moreover, cyclic changes in estrogen levels during the estrus cycle of female rats are associated with corresponding changes in the levels of activation of ERK2, the state of tyrosine phosphorylation of NR2 subunits of NMDA receptors, and the magnitude of long-term potentiation in hippocampus. Thus, cyclic changes in female sexual hormones result in marked variations in the state ofactivation of a major cellular signaling pathway critical for learning andmemory and in a cellular model of learning and memory.

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Documento generato il 20/01/21 alle ore 10:14:57