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Titolo:
Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP)
Autore:
Hashimoto, H; Shintani, N; Tanaka, K; Mori, W; Hirose, M; Matsuda, T; Sakaue, M; Miyazaki, J; Niwa, H; Tashiro, F; Yamamoto, K; Koga, K; Tomimoto, S; Kunugi, A; Suetake, S; Baba, A;
Indirizzi:
Osaka Univ, Grad Sch Pharmaceut Sci, Lab Mol Neuropharmacol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 armacol, Suita, Osaka 5650871, Japan Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 armacol, Suita, Osaka 5650871, Japan Osaka Univ, Grad Sch Med, Mol Pharmacol Lab, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 col Lab, Suita, Osaka 5650871, Japan Osaka Univ, Sch Med, Div Stem Cell Regulat Res, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 lat Res, Suita, Osaka 5650871, Japan
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 23, volume: 98, anno: 2001,
pagine: 13355 - 13360
SICI:
0027-8424(20011106)98:23<13355:APBIML>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; RECEPTOR MESSENGER-RNA; CENTRAL-NERVOUS-SYSTEM; IN-SITU HYBRIDIZATION; KNOCK-OUT MICE; RAT ASTROCYTES; GENE; EXPRESSION; MOUSE; DROSOPHILA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Baba, A Osaka Univ, Grad Sch Pharmaceut Sci, Lab Mol Neuropharmacol, 1-6 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 1-6 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
H. Hashimoto et al., "Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP)", P NAS US, 98(23), 2001, pp. 13355-13360

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) has been conserved remarkably during evolution and is widely expressed in the mammalian brain. In Drosophila, mutation of the PACAP homologue results in behavioral defects, including impaired olfaction-associated learning and changes in ethanol sensitivity. Here, we report the generation of mice lacking the PACAP gene (PACAP(-/-)). PACAP(-/-) mice were born in the expected Mendelian ratios but had a high early-mortality rate. The surviving adult PACAP(-/-) micedisplayed remarkable behavioral changes; they exhibited hyperactive and explosive jumping behaviors in an open field, increased exploratory behavior,and less anxiety in the elevated plus maze, emergence, and novel-object tests. Analysis of PACAP(-/-) mice brains revealed that the serotonin metabolite 5-hydroxyindoleacetic acid was slightly decreased in the cortex and striatum compared with wild-type mice. The present study provides evidence that PACAP plays a previously uncharacterized role in the regulation of psychomotor behaviors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:26:32