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Titolo:
Differentially expressed late constituents of the epidermal cornified envelope
Autore:
Marshall, D; Hardman, MJ; Nield, KM; Byrne, C;
Indirizzi:
Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 23, volume: 98, anno: 2001,
pagine: 13031 - 13036
SICI:
0027-8424(20011106)98:23<13031:DELCOT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSGLUTAMINASE SUBSTRATE PROPERTIES; STRATIFIED SQUAMOUS EPITHELIA; PROLINE-RICH PROTEINS; SKIN BARRIER FUNCTION; CELL ENVELOPES; GENE; LORICRIN; FAMILY; INVOLUCRIN; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Byrne, C Univ Manchester, Sch Biol Sci, 3-239 Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester 3-239 Stopford Bldg,Oxford Rd Manchester Lancs England M13 9PT
Citazione:
D. Marshall et al., "Differentially expressed late constituents of the epidermal cornified envelope", P NAS US, 98(23), 2001, pp. 13031-13036

Abstract

Barrier activity of skin and internal barrier-forming epithelial linings are conferred by a lipid-corneocyte structure (stratum corneum In skin). Theintegrity of the corneocytes depends on the outer cornified envelope and is essential for maintenance of barrier function. During epidermal development and differentiation, proteins are sequentially incorporated into the envelope via action of epidermal transglutaminases in a well documented process. However, recent knockouts of major cornified envelope constituents have failed to disrupt barrier function significantly, suggesting that additional unidentified components are involved. We report a new gene cluster in theepidermal differentiation complex at human 1q21 encoding a family of 18 proteins that are substrates for epidermal transglutaminases. These proteins incorporate into the cornified envelope late in development and late in theprocess of envelope maturation during epidermal differentiation. The genescluster within the epidermal differentiation complex according to expression pattern, i.e., epidermally expressed proteins cluster together while proteins from internal barrier-forming epithelia also cluster. We propose thatthese proteins modulate barrier activity over the surface of the animal, in a manner analogous to that proposed for the well characterized cornified envelope precursors, the small proline-rich proteins. To emphasize the incorporation of these proteins late in envelope assembly, we call the human proteins late envelope proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 15:13:14