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Titolo:
The use of magnesium sulfate to prevent seizures in the pre-eclamptic gravida: a cost-effectiveness analysis
Autore:
Blackwell, SC; Tomlinson, MW; Berman, S; Redman, ME; Hassan, SS; Berry, SM; Hallak, M; Sorokin, Y; Cotton, DB;
Indirizzi:
Wayne State Univ, Hutzel Hosp, Dept Obstet & Gynecol, Div Maternal Fetal Med, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 al Fetal Med, Detroit, MI 48201 USA
Titolo Testata:
PRENATAL AND NEONATAL MEDICINE
fascicolo: 5, volume: 6, anno: 2001,
pagine: 310 - 317
SICI:
1359-8635(200110)6:5<310:TUOMST>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE PREECLAMPSIA; HYPERTENSIVE DISORDERS; PEDIATRIC MORTALITY; CONTROLLED TRIAL; UNITED-KINGDOM; CEREBRAL-PALSY; WOMEN; MANAGEMENT; PREGNANCY; LABOR;
Keywords:
magnesium sulfate; seizure prophylaxis; pre-eclampsia; cost-effectiveness analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Blackwell, SC Wayne State Univ, Hutzel Hosp, Dept Obstet & Gynecol, Div Maternal Fetal Med, 4707 St Antoine Blvd, Detroit, MI 48201 USA Wayne State Univ 4707 St Antoine Blvd Detroit MI USA 48201 A
Citazione:
S.C. Blackwell et al., "The use of magnesium sulfate to prevent seizures in the pre-eclamptic gravida: a cost-effectiveness analysis", PRENAT N M, 6(5), 2001, pp. 310-317

Abstract

Objective To assess the costs, and outcomes of various strategies for seizure prophylaxis in pre-eclampsia in the United States. Methods A decision analysis model was constructed with magnesium sulfate as the anticonvulsant of choice. Three strategies were evaluated: no, anti-convulsant therapy; selective prophylaxis, for patients with severe pre-eclampsia; and universal prophylaxis for all patients with pre-eclampsia (severe and mild disease). Results Under baseline assumptions, selective therapy prevented 21 % of eclamptic seizures. The estimated cost for each seizure prevented would be $3333 and the cost for each death averted would be $166 667. Universal treatment would result in prevention of 35% of eclamptic seizures. The cost for each seizure prevented would be $6024 and the cost for each death averted would be $301 205. In a cost-effective comparison of the two magnesium sulfate treatment strategies, the incremental cost of universal prophylaxis would! be $9994 for every, additional seizure prevented and $469 000 for each additional death averted. Conclusions The universal prophylaxis of all preeclamptic women with magnesium sulfate appears to be cost-effective compared to the strategy of selected treatment of only those with severe disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:03:17