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Titolo:
Long-term effects of exogenous leptin on body weight and fat in post-obesefemale rats
Autore:
Buison, A; Ordiz, F; Jen, KLC;
Indirizzi:
Wayne State Univ, Dept Nutr & Food Sci, Detroit, MI 48202 USA Wayne State Univ Detroit MI USA 48202 r & Food Sci, Detroit, MI 48202 USA
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 3, volume: 74, anno: 2001,
pagine: 321 - 328
SICI:
0031-9384(200110)74:3<321:LEOELO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC NEUROPEPTIDE-Y; DIET-INDUCED OBESITY; PLASMA LEPTIN; GLUCOSE-UTILIZATION; ADIPOSE-TISSUE; MESSENGER-RNA; SERUM LEPTIN; ZUCKER RATS; IN-VIVO; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Jen, KLC Wayne State Univ, Dept Nutr & Food Sci, 3009 Sci Hall, Detroit, MI 48202 USA Wayne State Univ 3009 Sci Hall Detroit MI USA 48202 MI 48202 USA
Citazione:
A. Buison et al., "Long-term effects of exogenous leptin on body weight and fat in post-obesefemale rats", PHYSL BEHAV, 74(3), 2001, pp. 321-328

Abstract

This study was designed to test the hypothesis that short-term leptin infusion during the post-obese refeeding phase of weight-reduced rats would reduce the rate of weight regain and, as a result, reduce the final body weight and fat content in weight-reduced rats. Ninety-six female Wistar rats were divided into four groups: (1) LFCON (low-fat control) group: Rats in thisgroup were fed the control low-fat (LF) diet ad lib for the entire study period. (2) HFCON (high-fat control) group: Rats in this group were fed the high-fat (BF, 40% fat) diet ad lib for the study period. (3) HFRLP (high-fat fed, weight-reduced, leptin treatment) group: Obese rats in this group were weight-reduced and received leptin infusion for 2 weeks (miniosmotic pumps, 0.5 mug/kg/day) during the post-obese refeeding period. (4) HFRSM (high-fat fed, weight-reduced, sham control) group: Rats in this sham-control group were treated the same as the rats in the HFRLP group with the exceptionthat no leptin was actually infused during the first 2 weeks of refeeding period. The results demonstrated that 2 weeks of leptin treatment during the early refeeding phase did not prevent weight regain in weight-reduced rats, but it significantly reduced body fat content in these rats as compared to ad lib fed obese control rats. One cycle of weight reduction and regain did not alter the body weight and body fat content in HFRSM rats when compared to obese control rats. Therefore, leptin treatment was effective in reducing body fat content in post-obese rats for up to 7 weeks, but the long-term effect of short-term leptin treatment needs to be further examined. (C)2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:24:56