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Titolo:
Factors influencing behavior of group-housed male rats in the social interaction test Focus on cohort removal
Autore:
Kask, A; Nguyen, HP; Pabst, R; von Horsten, S;
Indirizzi:
Univ Tartu, Fac Med, Dept Pharmacol, EE-50090 Tartu, Estonia Univ Tartu Tartu Estonia EE-50090 ept Pharmacol, EE-50090 Tartu, Estonia Hannover Med Sch, Dept Funct & Appl Anat, D-30623 Hannover, Germany Hannover Med Sch Hannover Germany D-30623 nat, D-30623 Hannover, Germany
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 3, volume: 74, anno: 2001,
pagine: 277 - 282
SICI:
0031-9384(200110)74:3<277:FIBOGM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESS-INDUCED HYPERTHERMIA; ANTICIPATORY ANXIETY; MICE; DIAZEPAM; MODEL;
Keywords:
anticipation; anxiety; cohort removal; group housing; habituation; social interaction test; stress; transportation; Wistar rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kask, A Univ Tartu, Fac Med, Dept Pharmacol, Ravila 19, EE-50090 Tartu, Estonia Univ Tartu Ravila 19 Tartu Estonia EE-50090 -50090 Tartu, Estonia
Citazione:
A. Kask et al., "Factors influencing behavior of group-housed male rats in the social interaction test Focus on cohort removal", PHYSL BEHAV, 74(3), 2001, pp. 277-282

Abstract

The rat social interaction (SI) test is used widely to measure anxiety-like behavior, yet the influence of various factors such as testing time, pre-experimental manipulations (transport stress), and testing of animals from the same cage (cohort removal, CR) on SI has not been systematically studied. We measured SI behavior of male triad-housed Wistar rats in a novel dimly lit arena (low light unfamiliar, LU) and found that Sl time is higher in the beginning of the activity (dark) phase when compared with SI time in first half of the light phase. Furthermore, SI time is significantly increased by habituation of animals to the testing room during light phase, but this intervention has no effect in early dark phase when SI behavior is already maximal. Sequential removal of rats from the home cage led to the stress-like behavioral and physiological consequences. Rats removed in the last position had shorter SI time and higher body temperature. These data demonstrate that SI is higher during early dark vs. early light phase and confirm that CR has anxiogenic-like effects in rats. We conclude that the usage of sequentially removed group-housed rats in behavioral tests can be a source for considerable variation due to anxiety that develops in animals remainingin the cage. On the other hand, CR may be a useful method to study behavioral/neurochemical mechanisms of psychogenic stress in rats. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 29/02/20 alle ore 14:11:14