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Titolo:
Combination of drugs elevating extracellular adenosine with granulocyte colony-stimulating factor promotes granulopoietic recovery in the murine bonemarrow after 5-fluorouracil treatment
Autore:
Hofer, M; Pospisil, M; Weiterova, L; Znojil, V; Vacha, J; Hola, J; Vacek, A; Pipalova, I;
Indirizzi:
Acad Sci Czech Republ, Inst Biophys, CZ-61265 Brno, Czech Republic Acad Sci Czech Republ Brno Czech Republic CZ-61265 Brno, Czech Republic Masaryk Univ, Fac Med, Brno, Czech Republic Masaryk Univ Brno Czech Republic yk Univ, Fac Med, Brno, Czech Republic
Titolo Testata:
PHYSIOLOGICAL RESEARCH
fascicolo: 5, volume: 50, anno: 2001,
pagine: 521 - 524
SICI:
0862-8408(2001)50:5<521:CODEEA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
IRRADIATED MICE; ENHANCE;
Keywords:
5-fluorouracil; granulopoiesis; extracellular adenosine; adenosine monophosphate; dipyridamole; granulocyte colony-stimulating factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Hofer, M Acad Sci Czech Republ, Inst Biophys, Kralovopolska 135, CZ-61265 Brno, Czech Republic Acad Sci Czech Republ Kralovopolska 135 Brno Czech Republic CZ-61265
Citazione:
M. Hofer et al., "Combination of drugs elevating extracellular adenosine with granulocyte colony-stimulating factor promotes granulopoietic recovery in the murine bonemarrow after 5-fluorouracil treatment", PHYSL RES, 50(5), 2001, pp. 521-524

Abstract

Combined administration of drugs elevating extracellular adenosine, namelydipyridamole and adenosine monophosphate, together with granulocyte colony-stimulating factor was shown to enhance granulopoietic recovery in the bone marrow of mice treated with 5-fluorouracil. Enhanced regeneration was found both at the level of hematopoietic progenitor cells for granulocytes andmacrophages and in the compartment of morphologically recognizable granulocyte precursors. The results might have positive clinical impact. The adjunct use of drugs elevating extracellular adenosine might reduce the cost expenditure of therapy with granulocyte colony-stimulating factor.

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Documento generato il 08/04/20 alle ore 09:06:16