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Titolo:
The role of leptin in human physiology and pathophysiology
Autore:
Janeckova, R;
Indirizzi:
Inst Endocrinol, CZ-11694 Prague 1, Czech Republic Inst Endocrinol Prague Czech Republic 1 Z-11694 Prague 1, Czech Republic
Titolo Testata:
PHYSIOLOGICAL RESEARCH
fascicolo: 5, volume: 50, anno: 2001,
pagine: 443 - 459
SICI:
0862-8408(2001)50:5<443:TROLIH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC-OVARY-SYNDROME; MESSENGER-RNA LEVELS; OBESE GENE-PRODUCT; CORTICOTROPIN-RELEASING FACTOR; CEREBROSPINAL-FLUID LEPTIN; STEM NEURONAL-ACTIVITY; SERUM LEPTIN; OB GENE; PLASMA LEPTIN; BODY-WEIGHT;
Keywords:
leptin; obesity; puberty; body mass index; hormones; pregnancy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
163
Recensione:
Indirizzi per estratti:
Indirizzo: Janeckova, R Inst Endocrinol, Narodni Trida 8, CZ-11694 Prague 1, Czech Republic Inst Endocrinol Narodni Trida 8 Prague Czech Republic 1 blic
Citazione:
R. Janeckova, "The role of leptin in human physiology and pathophysiology", PHYSL RES, 50(5), 2001, pp. 443-459

Abstract

This review focuses on current knowledge of leptin biology and the role ofleptin in various physiological and pathophysiological states. Leptin is involved in the regulation of body weight. Serum leptin can probably be considered as one of the best biological markers reflecting total body fat in both animals and humans. Obesity in man is accompanied by increased circulating leptin concentrations. Gender differences clearly exist. Leptin is not only correlated to a series of endocrine parameters such as insulin, glucocorticoids, thyroid hormones, testosterone, but it also seems to be involvedin mediating some endocrine mechanisms (onset of puberty, insulin secretion) and diseases (obesity, polycystic ovary syndrome). It has also been suggested that leptin can act as a growth factor in the fetus and the neonate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:54:22