Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The "endorphin story": a subjective account
Autore:
Szekely, JI;
Indirizzi:
Inst Drug Res, Dept Pharmacol, H-1045 Budapest, Hungary Inst Drug Res Budapest Hungary H-1045 harmacol, H-1045 Budapest, Hungary
Titolo Testata:
PHARMAZIE
, volume: 56, anno: 2001, supplemento:, 1
pagine: S22 - S30
SICI:
0031-7144(200110)56:<S22:T"SASA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTINOCICEPTIVE CROSS-TOLERANCE; SYNTHETIC ENKEPHALIN ANALOG; NALORPHINE-LIKE DRUGS; MU-OPIATE RECEPTOR; CHRONIC SPINAL DOG; BETA-ENDORPHIN; FUNCTIONAL EXPRESSION; OPIOID RECEPTOR; MORPHINE-LIKE; C-FRAGMENT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Szekely, JI Inst Drug Res, Dept Pharmacol, Berlini Ut 47-49, H-1045 Budapest, Hungary Inst Drug Res Berlini Ut 47-49 Budapest Hungary H-1045 ungary
Citazione:
J.I. Szekely, "The "endorphin story": a subjective account", PHARMAZIE, 56, 2001, pp. S22-S30

Abstract

The contribution of the researchers of IDR to some early discoveries on endorphins is recounted. Exact determination of the amino acid sequence of beta -lipotropin, discovery of the analgesic action of beta -endorphin in rats, demonstration of the partial cross-tolerance between morphine and beta -endorphin, description of the elevation of the pain threshold upon inhibition of the enzymatic breakdown of endogenous opioids by bacitracin, demonstration of inhibition of opiate tolerance and dependence by alpha -MSH and Met-enkephalin, development of the second strongest enkephalin analogue, D-Met(2), Pro(5)-enkephalinamide, recognition of some factors conferring analgesic activity to synthetic enkephalin analogues, etc. prove that IDR has played an active role in the early history of endorphin research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:58:10