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Titolo:
Low doses of AMPA exert anticonvulsant effects on pentylenetetrazol-kindled seizures
Autore:
Becker, A; Grecksch, G; Schroeder, H;
Indirizzi:
Univ Magdeburg, Fac Med, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany Univ Magdeburg Magdeburg Germany D-39120 col, D-39120 Magdeburg, Germany
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2-3, volume: 70, anno: 2001,
pagine: 421 - 426
SICI:
0091-3057(200110/11)70:2-3<421:LDOAEA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA-RECEPTOR ANTAGONIST; HIPPOCAMPAL-NEURONS; GLUTAMATE-RECEPTOR; KAINATE RECEPTORS; ASPARTATE RELEASE; NONNMDA RECEPTORS; ABSENCE EPILEPSY; RAT; DESENSITIZATION; CYCLOTHIAZIDE;
Keywords:
AMPA; epilepsy; seizures; pentylenetetrazol kindling; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Becker, A Univ Magdeburg, Fac Med, Inst Pharmacol & Toxicol, Leipziger Str44, D-39120 Magdeburg, Germany Univ Magdeburg Leipziger Str 44 Magdeburg Germany D-39120 rmany
Citazione:
A. Becker et al., "Low doses of AMPA exert anticonvulsant effects on pentylenetetrazol-kindled seizures", PHARM BIO B, 70(2-3), 2001, pp. 421-426

Abstract

Excitatory amino acids (EAAs) are critically involved in the initiation and propagation of seizures. N-methyl-D-aspartate (NMDA) and alpha -amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors appear to be of special interest in this regard. Besides receptor binding by antagonists, the function of glutamatergic synapses can tie altered via autoreceptor-mediated mechanisms or by receptor desensitisation. Therefore, the effect of AMPA (1, 10 or 100 pmol per animal, intracerebroventricular injection) was tested on acutely induced pentylenetetrazol (PTZ) seizures. The lowest dose exerted clear anticonvulsant effects. Furthermore, 1 and 10 pmol AMPA were tested for their efficacy to suppress PTZ kindling. The lower dose reduced seizure severity significantly but 10 pmol AMPA was ineffective. In reaction toa test dose of PTZ, the kindled groups pretreated with AMPA reached seizure scores similar to saline-pretreated kindled rats, suggesting that the kindled state was reached. In a further experiment, we tested the effect of cyclothiazide (CYC, which blocks AMPA receptor desensitisation) on the 1 pmolAMPA-mediated anticonvulsant effect. The AMPA response was not altered. These results suggest that autoreceptor-mediated mechanisms rather than desensitisation might contribute to the anticonvulsant effect found. (C) 2001 Elsevier Science Inc. All fights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:10:52