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Titolo:
Early social isolation, but not maternal separation, affects behavioral sensitization to amphetamine in male and female adult rats
Autore:
Weiss, IC; Domeney, AM; Heidbreder, CA; Moreau, JL; Feldon, J;
Indirizzi:
ETH Zurich, Swiss Fed Inst Technol, Behav Neurobiol Lab, CH-8603 Schwerzenbach, Switzerland ETH Zurich Schwerzenbach Switzerland CH-8603 Schwerzenbach, Switzerland F Hoffmann La Roche & Co Ltd, CH-4002 Basel, Switzerland F Hoffmann La Roche & Co Ltd Basel Switzerland CH-4002 asel, Switzerland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2-3, volume: 70, anno: 2001,
pagine: 397 - 409
SICI:
0091-3057(200110/11)70:2-3<397:ESIBNM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRIATAL DOPAMINE RELEASE; ACOUSTIC STARTLE RESPONSE; OPEN-FIELD BEHAVIOR; PREPULSE INHIBITION; LATENT INHIBITION; ROTATIONAL BEHAVIOR; HOUSING CONDITIONS; LOCOMOTOR-ACTIVITY; SEX-DIFFERENCES; ENVIRONMENTAL STIMULI;
Keywords:
maternal separation; social isolation; sex differences; Sprague-Dawley strain; D-amphetamine; sensitization; locomotor activity; stereotypy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J ETH Zurich, Swiss Fed Inst Technol, Behav Neurobiol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland ETH Zurich Schorenstr 16 Schwerzenbach Switzerland CH-8603 land
Citazione:
I.C. Weiss et al., "Early social isolation, but not maternal separation, affects behavioral sensitization to amphetamine in male and female adult rats", PHARM BIO B, 70(2-3), 2001, pp. 397-409

Abstract

Early life stressful manipulations, such as maternal separation (MS) or social isolation (SI), can influence the neurobiological development of rats and alter the response of adult animals to drugs of abuse. The present study, examined the acute and sensitized behavioral responses (locomotor activity (LMA) and stereotypy) induced by amphetamine after MS or SI in male and female rats. In addition, the hypothesis that the combination of SI and MS could lead to additional effects on the behavioral response to amphetamine was tested. After the repetitive, intermittent administration of 1.5 mg/kg D-amphetamine over five consecutive days, the behavioral expression of sensitization to a challenge injection was assessed following a 2-day withdrawal period. In both sexes, MS and SI did not alter the acute locomotor activating effects of amphetamine as measured in the open-field environment afterthe first administration of the drug. Whereas SI altered the expression ofsensitization to amphetamine in both sexes, MS did not affect it. Finally,in none of the behavioral variables measured did MS and SI interact to further modify the behavioral profile of the animals. The present results suggest that a postweaning manipulation of the environment (SI) is more effective than a preweaning manipulation (MS) in modifying the expression of sensitization to amphetamine. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:04:52