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Titolo:
Discriminative stimulus properties of alpha-ethyltryptamine optical isomers
Autore:
Hong, SS; Young, R; Glennon, RA;
Indirizzi:
Virginia Commonwealth Univ, Sch Pharm, Dept Med Chem, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2-3, volume: 70, anno: 2001,
pagine: 311 - 316
SICI:
0091-3057(200110/11)70:2-3<311:DSPOAO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HALLUCINOGENS; RATS;
Keywords:
stimulants; hallucinogens; designer drugs; MDMA; amphetamine; PMMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Glennon, RA Virginia Commonwealth Univ, Sch Pharm, Dept Med Chem, 410 N 12th St,Box 980540 VCU,554A Smith Bldg, Richmond, VA 23298 USA Virginia Commonwealth Univ 410 N 12th St,Box 980540 VCU,554A Smith Bldg Richmond VA USA 23298
Citazione:
S.S. Hong et al., "Discriminative stimulus properties of alpha-ethyltryptamine optical isomers", PHARM BIO B, 70(2-3), 2001, pp. 311-316

Abstract

alpha -Ethyltryptamine (alpha -ET) possesses central stimulant and hallucinogenic activity. Also, in tests of stimulus generalization using rats trained to discriminate the controlled substance analog (i.e., designer drug) N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) from vehicle, alpha -ET substituted for MDMA. These previous studies employed racemic alpha-ET. Because psychoactive phenylalkylamines with abuse potential can produce one or more of three distinct stimulus effects (i.e., amphetamine-, DOM-and/or PMMA-like effects) in animals trained to discriminate either the stimulant (+)amphetamine, the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), or N-methyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA) from vehicle, and because these effects can be stereoselective, the individual optical isomers of alpha -ET were examined in groups of animals trainedto discriminate (+)amphetamine, DOM, PMMA and MDMA from saline vehicle. (-)alpha -ET (ED50 = 7.8 mg/kg), but not (+)alpha -ET (maximum of 53% drug-appropriate responding), substituted for (+)amphetamine, whereas (+)alpha -ET(ED50 = 2.7 mg/kg), but not (-)alpha -ET (maximum of 33% drug-appropriate responding), substituted for DOM. Both optical isomers of alpha -ET substituted for PMMA and MDMA with ED50 values of 1.6 and 1.4 mg/kg (PMMA-trained animals) and 1.3 and 2.0 mg/kg (MDMA-trained animals) for (-)alpha -ET and (+)alpha -ET, respectively. The results of this investigation suggest that both optical isomers of alpha -ET are capable of producing an MDMA/PMMA-like effect at nearly comparable doses, and that the stimulant or amphetamine-like nature of alpha -ET resides primarily with its ( -)isomer whereas hallucinogenic or DOM-like character resides primarily with the (+)enantiomer. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:43:35