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Titolo:
Chronic caffeine exposure in rats blocks a subsequent nicotine-conditionedtaste avoidance in a one-bottle, but not a two-bottle test
Autore:
Palmatier, MI; Bevins, RA;
Indirizzi:
Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA Univ Nebraska Lincoln NE USA 68588 a, Dept Psychol, Lincoln, NE 68588 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2-3, volume: 70, anno: 2001,
pagine: 279 - 289
SICI:
0091-3057(200110/11)70:2-3<279:CCEIRB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHARIN SOLUTION; NUCLEUS-ACCUMBENS; AREA POSTREMA; AVERSION; STIMULUS; DRUGS; ADENOSINE; DOPAMINE; ACETYLCHOLINE; AMPHETAMINE;
Keywords:
acetylcholine; adenosine; conditioned avoidance; dopamine; Pavlovian conditioning; rats; saccharin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bevins, RA Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA Univ Nebraska Lincoln NE USA 68588 chol, Lincoln, NE 68588 USA
Citazione:
M.I. Palmatier e R.A. Bevins, "Chronic caffeine exposure in rats blocks a subsequent nicotine-conditionedtaste avoidance in a one-bottle, but not a two-bottle test", PHARM BIO B, 70(2-3), 2001, pp. 279-289

Abstract

Two experiments were conducted in order to investigate nicotine-conditioned taste avoidance (CTA) following chronic preexposure to caffeine. Rats were given daily intraperitoneal injections of caffeine anhydrous (0, 10, or 30 mg/kg) for 10 or 30 days. Training of the nicotine-CTA began after the last day of caffeine preexposure. On five separate occasions access to a saccharin solution was followed immediately by an injection of 1.2 mg/kg nicotine hydrogen tartrate salt or saline. Nicotine-CTA readily developed in saline-preexposed controls. That is, paired rats drank less saccharin solution than unpaired rats after repeated saccharin-nicotine pairings. A similar pattern of nicotine-CTA was found for rats preexposed to 30 mg/kg caffeine for 10 days. Following 10 days of preexposure to 10 mg/kg caffeine, however, CTA did not develop under standard testing conditions. Thirty days of caffeine preexposure did not affect the development of a nicotine-CTA even though the anorexic effects of caffeine were evident after exposure to 30 mg/kg for this duration. Thus, caffeine exposure appears to weaken acquisition orexpression of the conditioned avoidance properties of nicotine. This effect is sensitive to the dose of caffeine and duration of preexposure. Importantly, the pattern of nicotine-CTA does not appear to be due to nonspecific effects of caffeine. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 06/04/20 alle ore 07:12:04