Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The contribution of mild thiamine deficiency and ethanol consumption to central cholinergic parameter dysfunction and rats' open-field performance impairment
Autore:
Pires, RGW; Pereira, SRC; Pittella, JEH; Franco, GC; Ferreira, CLM; Fernandes, PA; Ribeiro, AM;
Indirizzi:
Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Neuroquim, BR-31270010 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil BR-31270010 BC, MG, Brazil Univ Fed Minas Gerais, FAFICH, Dept Psicol, BR-31270010 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil BR-31270010 BC, MG, Brazil Univ Fed Minas Gerais, Fac Med, Dept Anat & Med Legal, BR-31270010 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil BR-31270010 BC, MG, Brazil Univ Fed Minas Gerais, ICEX, Dept Estatist, BR-31270010 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil BR-31270010 BC, MG, Brazil
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2-3, volume: 70, anno: 2001,
pagine: 227 - 235
SICI:
0091-3057(200110/11)70:2-3<227:TCOMTD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC ALCOHOL-CONSUMPTION; ACETYLCHOLINE METABOLISM; PROJECTION SYSTEM; BRAIN TRANSPLANTS; MEMORY DEFICITS; ANIMAL-MODELS; BEHAVIOR; NEURONS; CORTEX; ENCEPHALOPATHY;
Keywords:
ethanol; thiamine deficiency; acetylcholinesterase activity; acetylcholine release; cerebral cortex; hippocampus; open-field; Wistar rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Ribeiro, AM Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Neuroquim, BR-31270010 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil BR-31270010 BC
Citazione:
R.G.W. Pires et al., "The contribution of mild thiamine deficiency and ethanol consumption to central cholinergic parameter dysfunction and rats' open-field performance impairment", PHARM BIO B, 70(2-3), 2001, pp. 227-235

Abstract

We studied at the biochemical, morphological, and behavioral levels the effect of chronic ethanol consumption, associated or not with a mild thiaminedeficiency episode. We found that (i) thiamine deficiency induced a significant decrease of the acetylcholinesterase (AChE) activity both in cortex and hippocampus; (ii) chronic ethanol treatment has no effect on cortical AChE activity, but induced a significant decrease of hippocampal enzyme activity; (iii) the reduction in cortical and hippocampal AChE activity induced by chronic ethanol treatment associated with a 1-week thiamine deficiency was also significant and was greater than that induced by ethanol alone. Furthermore, either chronic ethanol or thiamine deficiency induced a significant decrease in the release of acetylcholine (ACh) in the stimulated condition using high potassium concentration; and when both treatments were associated the decrease was even greater. In the unstimulated condition, the reduction in the release of ACh was greater for ethanol treatment than for thiamine deficiency. Open-field tests showed that only in the "sniffing" category were there significant differences among the experimental groups. No morphological change was detected by optical microscopy, suggesting that the injury process was in its initial stages in which only functional and behavioral changes are displayed. In addition, our biochemical results indicate that cortical cholinergic susceptibilities to ethanol and thiamine deficiency are significantly different. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:21:38