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Titolo:
Sensitivity to the dopaminergic regulation of prepulse inhibition in rats:Evidence for genetic, but not environmental determinants
Autore:
Swerdlow, NR; Platten, A; Kim, YK; Gaudet, I; Shoemaker, J; Pitcher, L; Auerbach, P;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2-3, volume: 70, anno: 2001,
pagine: 219 - 226
SICI:
0091-3057(200110/11)70:2-3<219:STTDRO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOTYPAL PERSONALITY-DISORDER; RECEPTOR AGONIST SKF-82958; ACOUSTIC STARTLE RESPONSE; SCHIZOPHRENIC-PATIENTS; STRAIN DIFFERENCES; DEFICITS; REFLEX; HABITUATION; ENHANCEMENT; APOMORPHINE;
Keywords:
apomorphine; dopamine; genetics; prepulse inhibition; schizophrenia; startle; strain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Swerdlow, NR Univ Calif San Diego, Sch Med, Dept Psychiat, 9500 Gillman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gillman Dr La Jolla CA USA 92093 SA
Citazione:
N.R. Swerdlow et al., "Sensitivity to the dopaminergic regulation of prepulse inhibition in rats:Evidence for genetic, but not environmental determinants", PHARM BIO B, 70(2-3), 2001, pp. 219-226

Abstract

Prepulse inhibition (PPI), a measure of sensorimotor gating, is reduced inschizophrenia patients and in rats treated with dopamine (DA) agonists. Reported strain and supplier-based differences in sensitivity to PPI-disruptive effects of DA agonists presumably reflect the differential impact of genetics and/or environment on DAergic substrates regulating PPI. In 2000, Harlan Laboratories established a Texas Sprague-Dawley line (SDHt; facility 211) using breeders from Indianapolis (SDHi; facility 202A). SDHi rats had been used, approximately 11 years earlier, to establish a colony in San Diego(SDHsd; facility 235). SDHt and SDHi rats are thus genetically similar, but raised in distinct environments; approximately 11 years of genetic "drift" separates SDHsd rats from both SDHi and SDHt rats. Harlan Long-Evans hooded rats (LEH; Madison, WI, facility 207) are genetically distinct from albino SDH. All except SDHsd rats were shipped to our facility by air freight. We used SDHt, SDHi, SDHsd, and LEH rats to assess genetic and environmentalcontributions to the DAergic regulation of PPI. Acoustic startle/PPI were assessed in rats treated with the D1/D2 agonist apomorphine (APO), the D2 agonist quinpirole, or the D1 agonist SKF 82958. The relative sensitivities to the PPI-disruptive effects were: APO: SDHt=SDHsd=SDHi>>LEH; SKF 82958: SDHt = SDHsd = SDHi (LEH not sensitive); quinpirole: SDHt = SDHsd = SDHi; SDHi > LEH. Strain/supplier differences in sensitivity to drug effects on startle magnitude did not correspond to patterns of PPI sensitivity. In these rats, strain differences in the DAergic regulation of PPI are most easily explained by genetic, rather than environmental influences that differentially impact both D1 and D2 substrates. This finding is consistent with published reports in other strains. Pharmacogenetic studies of PPI in rats may identify a genetic basis for a model of deficient sensorimotor gating in schizophrenia. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:53:33