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Titolo:
HLA antigens in alkaptonuric patients
Autore:
Aliberti, G; Proietta, M; Pulignano, I; Tamburro, ML;
Indirizzi:
Univ Roma La Sapienza, Dept Clin Sci, I-00185 Rome, Italy Univ Roma La Sapienza Rome Italy I-00185 t Clin Sci, I-00185 Rome, Italy
Titolo Testata:
PANMINERVA MEDICA
fascicolo: 3, volume: 43, anno: 2001,
pagine: 145 - 148
SICI:
0031-0808(200109)43:3<145:HAIAP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANKYLOSING-SPONDYLITIS; OCHRONOSIS; ARTHROPATHY; COEXISTENCE; GENE;
Keywords:
alkaptonuria; HLA antigens; ochronosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Aliberti, G Policlin Umberto 1, Dipartimento Sci Clin, Viale Policlin, I-00161 Rome, Italy Policlin Umberto 1 Viale Policlin Rome Italy I-00161 e, Italy
Citazione:
G. Aliberti et al., "HLA antigens in alkaptonuric patients", PANMIN MED, 43(3), 2001, pp. 145-148

Abstract

Background. In alkaptonuric patients a disabilitating ochronotic arthropathy develops, due to the deposit of a pigmented polymer of homogentisic acid. Since in inherited diseases the clinical expressions may be multifactorial, involving genetic and environmental factors, where the HLA system may play a role, we studied HLA antigens in ochronotic patients. Methods. The study was carried out in 21 members of three families of six ochronotic patients and in two isolated ochronotic patients. The HLA typinghas been done testing for antigens from loci A, B and C, by international standard microlymphocytotoxicity method, and for loci DR and DQ, by fluorescence method on immunologically isolated cells by means of antibody-coated microspheres. The chi (2) test was used for statistical analysis, with Yates correction due to the low number of observations. Results. Despite the limited number of subjects, due to the rarity of the disease, a significantly higher prevalence of HLA-DR7 antigen was found in the alkaptonuric patients when compared to a general population (p <0.02), suggesting a possible association, while the prevalence of HLA A, B, C and DQ showed no significant differences. Conclusions. It might play a role in the pathophysiology and in the clinical expression of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:04:04