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Titolo:
A short synthetic pathway to a fully-functionalized southern hemisphere ofthe antitumor macrolide bryostatin 1
Autore:
Hale, KJ; Frigerio, M; Manaviazar, S;
Indirizzi:
Univ Coll London, Dept Chem, Christopher Ingold Labs, London WC1H 0AJ, England Univ Coll London London England WC1H 0AJ Labs, London WC1H 0AJ, England
Titolo Testata:
ORGANIC LETTERS
fascicolo: 23, volume: 3, anno: 2001,
pagine: 3791 - 3794
SICI:
1523-7060(20011115)3:23<3791:ASSPTA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VINYL RADICAL CYCLIZATION; DOUBLE-BOND FORMATION; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; CHEMOENZYMATIC SYNTHESIS; BIOLOGICAL EVALUATION; C-17-C-27 FRAGMENT; C1-C9 SEGMENT; ANALOGS; CONSTRUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Hale, KJ Univ Coll London, Dept Chem, Christopher Ingold Labs, 20 Gordon St, LondonWC1H 0AJ, England Univ Coll London 20 Gordon St London England WC1H 0AJ J, England
Citazione:
K.J. Hale et al., "A short synthetic pathway to a fully-functionalized southern hemisphere ofthe antitumor macrolide bryostatin 1", ORG LETT, 3(23), 2001, pp. 3791-3794

Abstract

[GRAPHICS]An 18-step asymmetric synthesis of the bryostatin 1 "southern hemisphere" fragment (1) has been developed. Key steps include an aldol reaction between 6 and 7 and a dehydration to establish the (E)-exocyclic alkene in 2 and a stereoselective Luche reduction and protection with TESOTf to access 1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:04:18