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Titolo:
Melatonin inhibits high voltage activated calcium currents in cultured ratdorsal root ganglion neurones
Autore:
Ayar, A; Martin, DJ; Ozcan, M; Kelestimur, H;
Indirizzi:
Firat Univ, Fac Med, Dept Pharmacol, TR-23200 Elazig, Turkey Firat Univ Elazig Turkey TR-23200 ept Pharmacol, TR-23200 Elazig, Turkey Univ Aberdeen, Inst Med Sci, Dept Biomed Sci, Aberdeen AB25 2ZD, Scotland Univ Aberdeen Aberdeen Scotland AB25 2ZD ci, Aberdeen AB25 2ZD, Scotland Firat Univ, Fac Med, Dept Biophys, TR-23200 Elazig, Turkey Firat Univ Elazig Turkey TR-23200 Dept Biophys, TR-23200 Elazig, Turkey Firat Univ, Fac Med, Dept Physiol, TR-23200 Elazig, Turkey Firat Univ Elazig Turkey TR-23200 Dept Physiol, TR-23200 Elazig, Turkey
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 313, anno: 2001,
pagine: 73 - 77
SICI:
0304-3940(20011102)313:1-2<73:MIHVAC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR CALCIUM; CHANNEL CURRENTS; SENSORY NEURONS; CELLS; PITUITARY;
Keywords:
melatonin; fura-2; sensory neurone; patch clamp; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Ayar, A Firat Univ, Fac Med, Dept Pharmacol, TR-23200 Elazig, Turkey FiratUniv Elazig Turkey TR-23200 macol, TR-23200 Elazig, Turkey
Citazione:
A. Ayar et al., "Melatonin inhibits high voltage activated calcium currents in cultured ratdorsal root ganglion neurones", NEUROSCI L, 313(1-2), 2001, pp. 73-77

Abstract

The actions of melatonin on high-voltage activated calcium channels (HVACC) and intracellular free Ca2+ concentration in cultured dorsal root ganglion (DRG) neurones from neonatal rats were investigated using the whole-cell patch clamp and the fura-2 fluorescence ratio Ca2+-imaging techniques. HVACC were pharmacologically and biophysically isolated and the effects of melatonin were investigated. Extracellular application of melatonin inhibited HVACC in a dose dependent manner. In calcium imaging experiments, application of extracellular recording medium containing 30 mM KCI evoked increases in intracellular free Ca2+ that were dependent upon external Ca2+ ions. Thisincrease was prevented by both low (10 muM) and high dose (100 muM) of melatonin pre-treatment. The results of this study indicate that the pineal hormone melatonin has inhibitory actions on voltage dependent calcium entry in cultured rat DRG neurones. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:07:20