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Titolo:
Epidermal growth factor down-regulates connexin-43 expression in cultured rat cortical astrocytes
Autore:
Ueki, T; Fujita, M; Sato, K; Asai, K; Yamada, K; Kato, T;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Bioregulat Res, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Hamamatsu Univ, Sch Med, Dept Anat & Neurosci, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Nagoya City Univ, Sch Med, Dept Neurosurg, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 313, anno: 2001,
pagine: 53 - 56
SICI:
0304-3940(20011102)313:1-2<53:EGFDCE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAP JUNCTION PROTEIN; PHOSPHORYLATION; RECEPTOR; NEURONS; BRAIN;
Keywords:
astrocyte; rat; cerebral cortex; connexin-43; epidermal growth factor; mitogen-activated protein kinase; the PD98059 MEK inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Ueki, T Nagoya City Univ, Sch Med, Dept Bioregulat Res, Mizuho Ku, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan Nagoya City Univ 1 Kawasumi,Mizuho Cho Nagoya Aichi Japan 4678601
Citazione:
T. Ueki et al., "Epidermal growth factor down-regulates connexin-43 expression in cultured rat cortical astrocytes", NEUROSCI L, 313(1-2), 2001, pp. 53-56

Abstract

Astrocytes are coupled via gap junction channels, predominantly formed by connexin-43 (Cx43), and contribute to neuronal function in the normal and diseased brain. In this study, we demonstrate that epidermal growth factor (EGF), applied to cortical astrocytes, results in a decrease in the expression of Cx43 mRNA and protein. We have further shown that the decrease is associated with the receptor tyrosine kinase pathway and the MEK inhibitor prevents EGF-stimulated down-regulation of Cx43 expression. These findings demonstrate a previously unknown function of EGF on cultured astrocytes, whichmay be relevant to the regulation of astrocytic growth and differentiation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:45:27