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Titolo:
Variations in extracellular monoamines in the prefrontal cortex and medialhypothalamus after modafinil administration: a microdialysis study in rats
Autore:
Hilaire, ZD; Orosco, M; Rouch, C; Blanc, G; Nicolaidis, S;
Indirizzi:
Univ Hosp Geneva, Sleep Lab, Div Adult Psychiat, CH-1225 Chene Bourg, Switzerland Univ Hosp Geneva Chene Bourg Switzerland CH-1225 hene Bourg, Switzerland Univ Paris 07, CNRS ESA 7059, F-75221 Paris 05, France Univ Paris 07 Paris France 05 7, CNRS ESA 7059, F-75221 Paris 05, France Coll France, INSERM U114, Chaire Neuropharmacol, F-75231 Paris, France Coll France Paris France F-75231 e Neuropharmacol, F-75231 Paris, France
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 12, anno: 2001,
pagine: 3533 - 3537
SICI:
0959-4965(20011116)12:16<3533:VIEMIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROMOTING DRUG MODAFINIL; POSTERIOR HYPOTHALAMUS; INDUCED WAKEFULNESS; DAYTIME SLEEPINESS; SEROTONIN RELEASE; PREOPTIC AREA; CONSCIOUS RAT; AMPHETAMINE; BRAIN; NARCOLEPSY;
Keywords:
dopamine; hypothalamus; microdialysis; modafinil; noradrenaline; prefrontal cortex; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hilaire, ZD Univ Hosp Geneva, Sleep Lab, Div Adult Psychiat, 2 Chemin Petit Bel Air, CH-1225 Chene Bourg, Switzerland Univ Hosp Geneva 2 Chemin PetitBel Air Chene Bourg Switzerland CH-1225
Citazione:
Z.D. Hilaire et al., "Variations in extracellular monoamines in the prefrontal cortex and medialhypothalamus after modafinil administration: a microdialysis study in rats", NEUROREPORT, 12(16), 2001, pp. 3533-3537

Abstract

The role of brain amines in mediating the effects of the wake-promoting agent modafinil, used in the treatment of sleepiness associated with narcolepsy is still uncertain. Therefore we studied the effects of modafinil on extracellular serotonin (5-HT), dopamine (DA) and noradrenaline (NA), in rat prefrontal cortex and in the medial hypothalamus area. Modafinil (128 mg/kg i.p,) significantly increased waking in the first 4h of EEG sleep recording. This cortical and behavioral activation was associated with an initial increase in extracellular 5-HT, DA and NA during the first 60 min following modafinil administration. In the prefrontal cortex, 5-HT release remained high for 3 h after modafinil administration. In contrast, in the hypothalamus, only NA release was enhanced while DA and 5-HT levels remained low. In a first step, modafinil may generate waking partly via cortical monoamine release, particularly DA and 5-HT, and also hypothalamic NA. In a second step,maintenance of waking might depend on hypothalamic NA. (C) 2001 LippincottWilliams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:53:18