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Titolo:
Melatonin protects against the effects of chronic stress on sexual behaviour in male rats
Autore:
Brotto, LA; Gorzalka, BB; LaMarre, AK;
Indirizzi:
Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 12, anno: 2001,
pagine: 3465 - 3469
SICI:
0959-4965(20011116)12:16<3465:MPATEO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MILD STRESS; DOG SHAKE BEHAVIOR; MEDIATED BEHAVIORS; RECEPTOR-BINDING; MODEL; NEUROTRANSMISSION; CORTICOSTERONE; ATTENUATION; ACTIVATION; DEPRESSION;
Keywords:
chronic mild stress; 5-HT2A receptors; melatonin; serotonin; sexual behaviour;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Gorzalka, BB Univ British Columbia, Dept Psychol, 2136 W Mall, Vancouver, BC V6T 1Z4, Canada Univ British Columbia 2136 W Mall Vancouver BC Canada V6T 1Z4
Citazione:
L.A. Brotto et al., "Melatonin protects against the effects of chronic stress on sexual behaviour in male rats", NEUROREPORT, 12(16), 2001, pp. 3465-3469

Abstract

The effects of chronic mild stress (CMS) on both sexual behaviour and wet dog shakes (WDS), a serotonergic type 2A (5-HT2A) receptor-mediated behaviour, were explored in the male rat In addition, the possible attenuation of these effects by chronic treatment with melatonin, a putative 5-HT2A antagonist, was examined. The CMS procedure resulted in a significant increase inWDS and an overall decrease in all aspects of sexual behaviour. Concurrentmelatonin administration attenuated the CMS-induced effects on sexual behaviour, but not the effects on either spontaneous WDS or WDS in response to the 5-HT2A agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, suggesting a mechanism of action other than exclusive 5-HT2A antagonism. These results are the first to demonstrate that melatonin significantly protects against the detrimental effects of a chronic stressor on sexual behaviour. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:15:13