Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Delta(9)-tetrahydrocannabinol-induced alterations in limbic system glucoseuse in the rat
Autore:
Brett, R; Mackenzie, F; Pratt, J;
Indirizzi:
Univ Paisley, Div Biol Sci, Paisley PA1 2BE, Renfrew, Scotland Univ Paisley Paisley Renfrew Scotland PA1 2BE PA1 2BE, Renfrew, Scotland Univ Strathclyde, Strathclyde Inst Biomed Sci, Dept Physiol & Pharmacol, Glasgow G4 0NR, Lanark, Scotland Univ Strathclyde Glasgow Lanark Scotland G4 0NR G4 0NR, Lanark, Scotland
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 12, anno: 2001,
pagine: 3573 - 3577
SICI:
0959-4965(20011116)12:16<3573:DAILSG>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; CANNABINOID RECEPTOR; MARIJUANA INTOXICATION; BRAIN; ACTIVATION; DELTA-9-TETRAHYDROCANNABINOL; PHARMACOLOGY; METABOLISM; ANANDAMIDE; BEHAVIOR;
Keywords:
cannabinoids; 2-deoxyglucose autoradiography; hippocampus; nucleus accumbens; somatosensory system; Delta(9)-tetrahydrocannabinol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Brett, R Univ Paisley, Div Biol Sci, Paisley PA1 2BE, Renfrew, Scotland Univ Paisley Paisley Renfrew Scotland PA1 2BE Renfrew, Scotland
Citazione:
R. Brett et al., "Delta(9)-tetrahydrocannabinol-induced alterations in limbic system glucoseuse in the rat", NEUROREPORT, 12(16), 2001, pp. 3573-3577

Abstract

The effects of Delta (9)-tetrahydrocannabinol (THC) on neural activity in the rat were investigated using [C-14]2-deoxyglucose autoradiography to measure local cerebral glucose use. Overall, THC reduced glucose use at 5 mg/kg and slightly increased it. at 1 mg/kg. Significant reductions were seen at the higher dose in regions of the hippocampus and limbic. system, and in structures associated with sensory and sensorimotor processing, consistent with the effects of-THC on memory, sensory perception and motor control. Glucose use was increased in the shell of the nucleus accumbens at 1 mg/kg but not reduced at 5 mg/kg. This may reflect increases in activity in mesolimbic reward pathways which at the higher dose are mitigated by reduced glutamatergic outflow from the hippocampus. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:19:55