Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats
Autore:
Sugawara, T; Yu, FS; Ma, L; Hsia, CJC; Chan, PH;
Indirizzi:
Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ept Neurosurg, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Neurol & Neurol Surg, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 & Neurol Surg, Stanford, CA 94305 USA Stanford Univ, Sch Med, Neurosci Program, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 rosci Program, Stanford, CA 94305 USA SynZyme Technol LLC, Irvine, CA USA SynZyme Technol LLC Irvine CA USASynZyme Technol LLC, Irvine, CA USA
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 12, anno: 2001,
pagine: 3609 - 3612
SICI:
0959-4965(20011116)12:16<3609:DTWPAR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; CUZN-SUPEROXIDE-DISMUTASE; ARTERY OCCLUSION; REPERFUSION; NITROXIDE; DAMAGE; INJURY; HEMODILUTION; RADICALS; TEMPOL;
Keywords:
delayed treatment; focal cerebral ischemia; neuroprotection; nitroxides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Chan, PH Stanford Univ, Sch Med, Dept Neurosurg, 1201 Welch Rd,MSLS P314, Stanford,CA 94305 USA Stanford Univ 1201 Welch Rd,MSLS P314 Stanford CA USA94305 5 USA
Citazione:
T. Sugawara et al., "Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats", NEUROREPORT, 12(16), 2001, pp. 3609-3612

Abstract

Nitroxides are antioxidants that are known to protect cells from oxidativedamage. Polynitroxyl albumin (PNA) is a compound of human serum albumin covalently labeled with nitroxides that exhibits a prolonged half-life and anenhanced antioxidant activity. Adult male Sprague-Dawley rats were subjected to 90 min intraluminal middle cerebral artery occlusion and the drug wasadministered intravenously immediately or 2 h after reperfusion. The effects of the drug were evaluated 24 h after reperfusion. Infarct volume was significantly reduced in immediate (79% reduction) and delayed (53% reduction) PNA-treated groups. The efficacy of a single, delayed i.v. injection of PNA suggests that PNA has great promise in the treatment of acute human stroke. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 01:07:06