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Titolo:
Chronic exposure of kainate and NBQX changes AMPA toxicity in hippocampal slice cultures
Autore:
Jakobsen, B; Zimmer, J;
Indirizzi:
SDU Odense Univ, Inst Med Biol, Neurosci PharmaBiotec, DK-5000 Odense C, Denmark SDU Odense Univ Odense Denmark C PharmaBiotec, DK-5000 Odense C, Denmark
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 12, anno: 2001,
pagine: 3593 - 3597
SICI:
0959-4965(20011116)12:16<3593:CEOKAN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE RECEPTOR SUBUNIT; RAT HIPPOCAMPUS; CLONING; ACID; EXPRESSION; BRAIN; ANTAGONIST; ISCHEMIA; FAMILY; CELLS;
Keywords:
brain slice cultures; kainate; NBQX; propidium iodide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Jakobsen, B SDU Odense Univ, Inst Med Biol, Neurosci PharmaBiotec, Winsloewpk 21, DK-5000 Odense C, Denmark SDU Odense Univ Winsloewpk 21 Odense Denmark C nse C, Denmark
Citazione:
B. Jakobsen e J. Zimmer, "Chronic exposure of kainate and NBQX changes AMPA toxicity in hippocampal slice cultures", NEUROREPORT, 12(16), 2001, pp. 3593-3597

Abstract

Receptor agonist/antagonist mediated modulation of the excitotoxic effect of AMPA was studied in organotypic hippocampal slice cultures. Treatment ofdeveloping cultures for 2 weeks with a subtoxic dose of 2 muM kainate reduced the toxicity of 3 muM AMPA, applied for 48 h with 24 h of recovery, as measured by cellular uptake of the fluorescent dye propidium iodide. In contrast long-term treatment with 0.3 muM of the AMPA/KA antagonist NBQX increased the susceptibility of the cultures to an even lower dose of 2 muM AMPA. The modulatory effects of long-term application of low doses of kainate and NBQX, have implications for the development and use of related drugs that aim to protect against glutamate receptor-mediated disturbances. (C) 2001Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:32:45