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Titolo:
Altered calcium dynamics in cultured cerebellar cells from IP3RI-deficientmice
Autore:
Matsumoto, M; Kato, K;
Indirizzi:
RIKEN, Inst Phys & Chem Res, Dev Neurobiol Lab, Wako, Saitama 3510106, Japan RIKEN Wako Saitama Japan 3510106 robiol Lab, Wako, Saitama 3510106, Japan Univ Tokyo, Fac Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 psychiat, Bunkyo Ku, Tokyo 1138655, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 12, anno: 2001,
pagine: 3471 - 3474
SICI:
0959-4965(20011116)12:16<3471:ACDICC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; CENTRAL-NERVOUS-SYSTEM; CA2+ RELEASE CHANNELS; RYANODINE RECEPTORS; PURKINJE NEURONS; EXPRESSION;
Keywords:
ataxia; Ca2+-induced-Ca2+-release (CICR); granule cell; inositol 1,4,5-trisphosphate receptor (IP3R); IP3-induced-Ca2+-release (IICR); knock-out mouse; long-term depression (LTD); Opisthotonos mouse (Opt mouse); primary culture; Purkinje cell; synaptic plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumoto, M Mitsubishi Kasei Inst Life Sci, Inokuchi Plastic & Memory Unit, 11 Minamiooya, Tokyo 1948511, Japan Mitsubishi Kasei Inst Life Sci 11 Minamiooya Tokyo Japan 1948511
Citazione:
M. Matsumoto e K. Kato, "Altered calcium dynamics in cultured cerebellar cells from IP3RI-deficientmice", NEUROREPORT, 12(16), 2001, pp. 3471-3474

Abstract

Intracellular calcium release in response to bath-applied quisqualate or caffeine was examined in cerebellar primary cultures of type-I-inositol-1,4,5-trisphosphate-receptor (IP(3)R1)deficient mice. Under [Ca2+](o)-free conditions, calcium release in response to 10 muM quisqualate was significantlyreduced in Purkinje cells, but was unaffected in granule cells, suggestingthat different subtypes of IP3 receptors contribute to the metabotropic glutamate response in these cells. In addition, calcium release in response to 10 mM caffeine under [Ca2+](o)-free conditions was not impaired in cerebellar cells, suggesting that IICR and CICR are independentty regulated in cerebellar cells. Moreover, in both wild-type and homozygous mutant mice, CICin granule cells was similar to6 times greater than in Purkinje cells. (C)2001 Lippincott Williams & Wilkins.

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Documento generato il 11/07/20 alle ore 20:51:41