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Titolo:
Repolarization of the plasma membrane shapes NMDA-induced cytosolic [Ca2+]transients
Autore:
Kiedrowski, L;
Indirizzi:
Univ Illinois, Coll Med, Dept Pharmacol & Psychiat, Inst Psychiat, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 , Inst Psychiat, Chicago, IL 60612 USA
Titolo Testata:
NEUROREPORT
fascicolo: 16, volume: 12, anno: 2001,
pagine: 3579 - 3582
SICI:
0959-4965(20011116)12:16<3579:ROTPMS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE CELLS; RAT HIPPOCAMPAL-NEURONS; MITOCHONDRIAL DEPOLARIZATION; CALCIUM-CONCENTRATION; INTRACELLULAR SODIUM; NA+/CA2+ EXCHANGE; FOREBRAIN NEURONS; GLUTAMATE; EXCITOTOXICITY; NA+;
Keywords:
depolarization; DiBAC(4)(3); fura-2; lithium; mitochondria; Na/Ca exchange; neurons; nifedipine; ouabain; SBFI; sodium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kiedrowski, L Univ Illinois, Coll Med, Dept Pharmacol & Psychiat, Inst Psychiat, 1601 W Taylor St,Room 334W, Chicago, IL 60612 USA Univ Illinois 1601W Taylor St,Room 334W Chicago IL USA 60612
Citazione:
L. Kiedrowski, "Repolarization of the plasma membrane shapes NMDA-induced cytosolic [Ca2+]transients", NEUROREPORT, 12(16), 2001, pp. 3579-3582

Abstract

After inactivation of NMDA receptors, restoration of basal cytosolic [Ca2+] ([Ca2+](c)) is delayed. This may be caused by Ca2+ influx via reverse Na/Ca exchange or voltage-gated Ca2+ channels, and/or by Ca2+ efflux from internal stores. Monitoring of [Na+](c), [Ca2+](c), and plasma membrane potential in cultured cerebellar granule cells showed that repolarization. of the plasma membrane and inactivation of voltage-gated Ca channels plays the most critical role in restoration of low [Ca2+](c) following NMDA receptor inactivation. During NMDA receptor activation, however, an Na-dependent mechanism enhanced NMDA-incluced elevation in [Ca2+](c). This mechanism did not involve Na,K-ATPase activation by Na+ because it operated even when Na,K-ATPase was inhibited. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:26:14